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Title of Journal: Curr Neurol Neurosci Rep

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Abbravation: Current Neurology and Neuroscience Reports

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Current Science Inc.

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DOI

10.1016/0925-4005(95)01752-h

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1534-6293

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Antiepileptic Drugs and Neurodevelopment An Updat

Authors: Susan Palac Kimford J Meador
Publish Date: 2011/04/05
Volume: 11, Issue: 4, Pages: 423-427
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Abstract

In utero exposure to some antiepileptic drugs AEDs is associated with an increased risk of impaired cognitive development Specifically valproate and polytherapy exposure are each associated with an increased risk of cognitive impairment in children compared with other antiepileptic medications The data regarding the risk to neurocognitive development imposed by maternal use of other AEDs are conflicting or insufficient at this time to draw definitive conclusions Behavioral dysfunction including autistic spectrum disorder is also associated with maternal use of AEDs during pregnancy Whether treatment with AEDs during childhood permanently affects cognitive neurodevelopment is yet to be determinedKJ Meador has received a grant from the National Institutes of Health NIH has been a consultant on grants for NIH has been a Primary Investigator for a grant from NIH/National Institute of Neurological Disorders and Stroke has been a Coinvestigator on a grant from NIH/National Center on Minority Health and Health Disparities and has been a Coinvestigator on a grant from NIHConflicts of interest S Palac none KJ Meador has been a Coinvestigator on a grant from Epilepsy Foundation of America has been a Primary Investigator for a grant from Pfizer Pharmaceuticals has been a Primary Investigator and Coinvestigator for grants from UCB Pharma has been a Coinvestigator on grants from Neuropace Inc has been a Primary Investigator for a grant from GlaxoSmithKline has been a Primary Investigator for a grant from Schwartz Biosciences UCB Pharma has been a Coinvestigator on a grant from Marinus Pharmaceuticals Inc has been a Coinvestigator on a grant from Myriad Pharmaceuticals Inc has traveled to speak for Sanofi Aventis is on the editorial board for the journal Epilepsy Currents and is a member of the professional advisory board for the Epilepsy Foundation of America

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Other Papers In This Journal:
  1. Neurological Complications of the Leukemias Across the Ages
  2. Biological approaches to aphasia treatment
  3. The Use of Targeted Temperature Management for Elevated Intracranial Pressure
  4. Tonabersat: A Cortical Spreading Depression Inhibitor as Potential Pharmacologic Prophylaxis in Migraine with Aura
  5. Translational research in stroke: Taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials
  6. New Information on the Genetics of Stroke
  7. The Role of Brain Tumor Advocacy Groups
  8. Developments in the Role of Transcranial Sonography for the Differential Diagnosis of Parkinsonism
  9. Axons to Exons: the Molecular Diagnosis of Rare Neurological Diseases by Next-Generation Sequencing
  10. Normal pressure hydrocephalus: Diagnosis and treatment
  11. New concepts in perinatal hypoxia ischemia encephalopathy
  12. Diagnosis and Treatment of Idiopathic Intracranial Hypertension (IIH) in Children and Adolescents
  13. Drug delivery to brain tumors
  14. Limb–Girdle and Congenital Muscular Dystrophies: Current Diagnostics, Management, and Emerging Technologies
  15. An update on primary progressive aphasia
  16. Neurogenetics in Child Neurology: Redefining a Discipline in the Twenty-first Century
  17. Variability in recovery from aphasia
  18. Research with transcranial magnetic stimulation in the treatment of aphasia
  19. Chronic pain rehabilitation in chronic headache disorders
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