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Title of Journal: Curr Neurol Neurosci Rep

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Abbravation: Current Neurology and Neuroscience Reports

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Current Science Inc.

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DOI

10.1007/bf02993222

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1534-6293

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Tonabersat A Cortical Spreading Depression Inhibi

Authors: Ivan Garza
Publish Date: 2010/01/12
Volume: 10, Issue: 1, Pages: 7-9
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Abstract

Headache research was very limited before the 1980s Since then a better understanding of migraine pathophysiology has gradually surfaced Cortical spreading depression CSD is a neurophysiologic phenomenon that since its discovery by Leão has been amply investigated and is now widely recognized as the neurophysiologic substrate of migraine aura 1 SB220453 now known as tonabersat is a benzoylaminobenzopyran compound that has shown the ability to inhibit CSD in animal models of migraine 2 Great interest has developed with regard to the possibility that pharmacologic CSD inhibition may prevent migraine headache attacks although in a human model of migraine tonabersat failed as a preemptive antimigraine agent in a doubleblind study 2 For prophylaxis

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Other Papers In This Journal:
  1. Neurological Complications of the Leukemias Across the Ages
  2. Biological approaches to aphasia treatment
  3. The Use of Targeted Temperature Management for Elevated Intracranial Pressure
  4. Translational research in stroke: Taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials
  5. New Information on the Genetics of Stroke
  6. The Role of Brain Tumor Advocacy Groups
  7. Developments in the Role of Transcranial Sonography for the Differential Diagnosis of Parkinsonism
  8. Axons to Exons: the Molecular Diagnosis of Rare Neurological Diseases by Next-Generation Sequencing
  9. Normal pressure hydrocephalus: Diagnosis and treatment
  10. New concepts in perinatal hypoxia ischemia encephalopathy
  11. Diagnosis and Treatment of Idiopathic Intracranial Hypertension (IIH) in Children and Adolescents
  12. Drug delivery to brain tumors
  13. Limb–Girdle and Congenital Muscular Dystrophies: Current Diagnostics, Management, and Emerging Technologies
  14. An update on primary progressive aphasia
  15. Neurogenetics in Child Neurology: Redefining a Discipline in the Twenty-first Century
  16. Variability in recovery from aphasia
  17. Research with transcranial magnetic stimulation in the treatment of aphasia
  18. Antiepileptic Drugs and Neurodevelopment: An Update
  19. Chronic pain rehabilitation in chronic headache disorders
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