Effect of channel block on the collective spiking

Authors: YuBing Gong Bo Xu XiaoGuang Ma JiQu Han

Publish Date: 2008/04/01

Volume: 51, Issue: 4, Pages: 341-346

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Abstract

Toxins such as tetraethylammonium TEA and tetrodotoxin TTX can make potassium or sodium ion channels poisoned respectively and hence reduce the number of working ion channels and lead to the diminishment of conductance In this paper we have studied by numerical simulations the effects of sodium and potassium ion channel poisoning on the collective spiking activity of an array of coupled stochastic HodgkinHuxley HH neurons It is found for a given number of neurons sodium or potassium ion channel block can either enhance or reduce the collective spiking regularity depending on the membrane patch size For a given smaller or larger patch size potassium and sodium ion channel block can reduce or enhance the collective spiking regularity but they have different patch size ranges for the transformation This result shows that sodium or potassium ion channel block might have different effects on the collective spiking activity in coupled HH neurons from the effects for a single neuron which represents the interplay among the diminishment of maximal conductance and the increase of channel noise strength due to the channel blocks as well as the bidirectional coupling between the neurons

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