Effect of gating currents of ion channels on the c

Authors: YuBing Gong YanHang Xie Bo Xu XiaoGuang Ma

Publish Date: 2009/01/13

Volume: 52, Issue: 1, Pages: 20-25

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Abstract

Based on the coupled stochastic HodgkinHuxley neurons we numerically studied the effect of gating currents of ion channels as well as coupling and the number of neurons on the collective spiking rate and regularity in the coupled system It was found for a given coupling strength and with a relatively large number of neurons when gating currents are applied the collective spiking regularity decreases meanwhile the collective spiking rate increases indicating that gating currents can aggravate the desynchronization of the spikings of all neurons However gating currents caused hardly any effect in the spiking of any individual neuron of the coupled system This result different from the reduction of the spiking rate by gating currents in a single neuron provides a new insight into the effect of gating currents on the global information processing and signal transduction in real neural systems

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