Lupus and Pregnancy—15 Years of Experience in a Te

Authors: Paula Ambrósio Rita Lermann Alexandra Cordeiro Augusta Borges Isabel Nogueira Fátima Serrano

Publish Date: 2009/06/27

Volume: 38, Issue: 2-3, Pages: 77-81

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Abstract

This retrospective study was designed to evaluate the outcome of pregnancies in women diagnosed with systemic lupus erythematosus SLE followed in a tertiary fetal–maternal center Data were collected from clinical charts between January 1993 and December 2007 with a total of 136 pregnancies 107 patients Mean maternal age was 29 years with the vast majority of patients being Caucasian Most patients were in remission 6 months prior to pregnancy 93 and the most frequently affected organs were the skin and joints Renal lupus accounted for 14 of all cases Twentynine percent of patients were positive for at least one antiphospholid antibody aPL and nearly 50 had positive SSa/SSb antibodies All patients with positive aPL received lowdosage aspirin and lowmolecularweight heparin LMWH There were no pregnancy complications in more than 50 of cases and hypertensive disease and intrauterine growth restriction were the most common adverse events There were 125 live births one neonatal death eight miscarriages and three medical terminations of pregnancy Preterm delivery occurred in 25 of pregnancies Our results are probably the conjoined result of a multidisciplinary approach together with a systematic management of SLE pregnancies with most patients keeping their prior SLE medication combined with lowdosage aspirin and LMWH in the presence of aPL

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