Changing incidence of gastric and oesophageal canc

Authors: Adrian Schmassmann MarieGabrielle Oldendorf JanOlaf Gebbers

Publish Date: 2009/08/09

Volume: 24, Issue: 10, Pages: 603-609

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Abstract

Several Western countries have reported a decrease in the incidence of noncardia gastric adenocarcinoma and a strong increase in the incidence of oesophageal and cardia adenocarcinoma We examined incidence rates of gastric and oesophageal cancer by subsite and histology in Central Switzerland over the last 26 years Data on biopsydiagnosed gastric and oesophageal carcinoma incidence during 1982–2007 were obtained from the Cancer Registry of the Institute of Pathology Lucerne the Medical Centre for Central Switzerland Ageadjusted standardized to the European standard population and sexspecific incidence rates were calculated In total 2322 cancers were diagnosed 1240 noncardia gastric adenocarcinomas 459 cardia gastric adenocarcinomas 248 oesophageal adenocarcinomas and 375 squamous cell carcinomas From 1982 to 2007 the incidence rates of noncardia adenocarcinoma decreased substantially from 179 per 100000 to 60 in men and 103 to 55 in women In men the incidence of gastric cardia adenocarcinoma decreased from 75 to 43 the incidence of oesophageal adenocarcinoma increased from 33 to 48 and the incidence of oesophageal squamous cell carcinoma decreased from 66 to 41 the incidence rates of these cancers were low in women 11–24 In conclusion the incidence of gastric noncardia carcinoma has decreased substantially over the past 26 years In contrast to other Western countries the incidence of gastric cardia adenocarcinoma did not increase in Central Switzerland Whereas the rate of oesophageal adenocarcinoma increased the rate of squamous cell carcinoma decreased These results suggest substantial changes in environmental and lifestyle risk factors over the past 26 years

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