Smoking physical exercise BMI and late foetal de

Authors: Maria MoralesSuárezVarela Ellen A Nohr Bodil H Bech Chunsen Wu Jørn Olsen

Publish Date: 2016/08/17

Volume: 31, Issue: 10, Pages: 999-1009

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Abstract

The aim of this paper was to estimate the effect of maternal and paternal smoking on foetal death miscarriage and stillbirth and to estimate potential interactions with physical exercise and prepregnancy body mass index We selected 87930 pregnancies from the populationbased Danish National Birth Cohort Information about lifestyle occupational medical and obstetric factors was obtained from a telephone interview and data on pregnancy outcomes came from the Danish population based registries Cox regression was used to estimate the hazard ratios adjusted for potential confounders for predominantly late foetal death miscarriage and stillbirth An interaction contrast ratio was used to assess potential effect measure modification of smoking by physical exercise and body mass index The adjusted hazard ratio of foetal death was 122 95  CI 102–146 for couples where both parents smoked compared to nonsmoking parents miscarriage 118 95  CI 096–144 stillbirth 132 95  CI 093–189 On the additive scale we detected a small positive interaction for stillbirth between smoking and body mass index overweight women In conclusion smoking during pregnancy was associated with a slightly higher hazard ratio for foetal death if both parents smoked This study suggests that smoking may increase the negative effect of a high BMI on foetal death but results were not statistically significant for the interaction between smoking and physical exercise

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