Authors: Byung Ha Lee Mauro A Tudares Cuong Q Nguyen
Publish Date: 2009/02/14
Volume: 57, Issue: 1, Pages: 57-66
Abstract
Sjögren’s syndrome SjS is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands respectively The pathogenesis of the disease remains elusive perhaps due to the multiple triggers of the disease However substantial advances have been made in attempting to resolve the complexity of SjS using both animal models and human subjects The primary objectives of this review are to provide a better understanding of the disease processes with major emphasis on the use of mouse models how genetic predisposition plays a role in the natural history of the disease as well as a presentation of new findings pertaining to the role of TH1 TH2 and TH17 cells in the pathogenesis of SjS
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