Matrix Metalloproteinases and Their Inhibitors in

Authors: Zdenka Navratilova Vitezslav Kolek Martin Petrek

Publish Date: 2015/11/26

Volume: 64, Issue: 3, Pages: 177-193

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Abstract

Chronic obstructive pulmonary disease COPD is characterised by irreversible airflow limitation associated with chronic inflammation Matrix metalloproteinases MMPs are proteolytic enzymes that contribute to the inflammatory response in COPD and degrade extracellular matrix components Their enzymatic activity is inhibited by a fourmember family of tissue inhibitors of metalloproteinases TIMPs In COPD the MMP/TIMP network mainly MMP9 has been repeatedly observed to be dysregulated at both the local lung and systemic levels Here we review the findings reported in numerous crosssectional studies with our primary focus on longitudinal observations in human COPD studies The data from longitudinal prospective studies on the MMP/TIMP network may lead to the introduction of novel prognostic biomarkers into clinical management of COPD We address the relationship between the systemic and local lung MMP/TIMP network in COPD patients and briefly describe the involvement of microRNAs Finally the role of the MMP/TIMP network in COPD treatment is discussed

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