Authors: Bodo Cremers Melanie Biedermann Dirk Mahnkopf Michael Böhm Bruno Scheller
Publish Date: 2009/03/12
Volume: 98, Issue: 5, Pages: 325-330
Abstract
Drugeluting balloon DEB catheters coated with paclitaxel in a watersoluble matrix have shown beneficial effects in the treatment and prevention of restenosis in the porcine coronary overstretch model and in clinical trials Adherence of paclitaxel same dose on another recently introduced coated percutaneous coronary intervention PCI catheter DIOR® is mediated by a roughened balloon surface Only scarce experimental and clinical data has been published on the new coating method The aim of the present study was to compare the safety and efficacy of the two coatings in the porcine modelTwentyeight stainless steel stents were implanted in the left anterior descending and circumflex coronary arteries of 14 domestic pigs using either matrixcoated n = 8 roughened DEB n = 9 or uncoated PCI catheters which served as control n = 11 After 28 days quantitative angiography and histomorphometry of the stented arteries were performed Matrixcoated DEB led to a highly significant P 001 reduction of all parameters indicating neointimal proliferation compared to both uncoated control and the roughened DEB late lumen loss insegment was 04 ± 02 19 ± 05 and 14 ± 05 mm respectively In contrast the roughened DEB failed to produce statistically significant effects on angiographic measures of stenosis or morphometric parameters such as maximal neointimal thickness and luminal area except for neointimal area 57 ± 15 mm2 in the control group 41 ± 17 mm2 roughened DEB P 005 vs control and 25 ± 08 mm2 matrixcoated DEB P 001 vs control
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