Expression of Syk in nonsmall cell lung cancer an

Authors: Fen Lan Shengdao Xiong Weining Xiong Guopeng Xu Xiaoxia Lu

Publish Date: 2009/03/12

Volume: 3, Issue: 1, Pages: 41-44

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Abstract

This study aims to research the expression of spleen tyrosine kinase Syk in nonsmall cell lung cancer NSCLC and the relationship between Syk and clinicopathologic factors and p53 Immunohistochemistry was applied to detect the expression of Syk and p53 protein in 39 cases of NSCLC 23 cases of lung squamous cell cancer 16 cases of lung adenocarcinoma and tumorsurrounding normal lung tissues The positive rate of Syk was 4615 18/39 and 100 39/39 in NSCLC and tumorsurrounding normal lung tissues respectively The expression level of Syk in NSCLC was significantly lower than that in tumorsurrounding normal lung tissues P = 0000 The Syk expression was positively correlated with the p53 expression in NSCLC specimens P = 0025 There was no significant association between Syk expression and lymph node metastasis differentiation degree tumor size and tumor node metastasis TNM The present study demonstrated that Syk was aberrantly expressed in the NSCLC and might have a significant impact on tumor growth and progression

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