Immunohistochemical Study for IgG4positive Plasma

Authors: Hiroshi Nishioka Makoto Shibuya Jo Haraoka

Publish Date: 2010/07/16

Volume: 21, Issue: 4, Pages: 236-241

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Abstract

On histology IgG4related hypophysitis is essentially similar to lymphocytic hypophysitis besides massive IgG4positive plasmacyte infiltration This immunohistochemical study was performed to investigate the presence of IgG4positive plasmacytes in 14 various inflammatory lesions Five cases of lymphocytic hypophysitis and a case of granulomatous hypophysitis were either negative or showed only a few IgG4postive cells A case of hypophysitis associated with pachymeningitis and a case of pituitary invasion of lymphoma were IgG4 negative On the other hand some IgG4positive cells that tended to accumulate were observed in every six cases of secondary inflammation In conclusion immunohistochemistry for IgG4 can be a clue for differentiating IgG4related hypophysitis from lymphocytic hypophysitis However clusters of IgG4positive plasmacytes could be observed in secondary inflammation Diagnosing hypophysitis with small biopsy specimen still remains troublesomeWe declare that we have no conflict of interest that could be perceived as prejudicing the impartiality of the research reported We did not receive any specific grant from any funding agency in the public commercial or notforprofit sector We are grateful to Prof J Patrick Barron of the Department of International Medical Communications of Tokyo Medical University for the review of this manuscript

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