Solitary Fibrous Tumor of the Adrenal Gland with U

Authors: Yong Howe Ho Wai Ming Yap Khoon Leong Chuah

Publish Date: 2010/02/27

Volume: 21, Issue: 2, Pages: 125-129

PDF Link

Abstract

Solitary fibrous tumor was initially thought to be a pleurabased tumor However over the last two decades its involvement in a variety of extrapleural sites gained recognition Nonetheless a primary involvement of the endocrine organs is rare and in this report we detail an instance where the tumor affected the adrenal gland of a 71yearold Arab man On histology besides the typical morphologic features seen in solitary fibrous tumor the neoplasm also exhibited unusual features on immunohistochemistry such as positive staining for cytokeratin AE1/3 and calponin in conjunction with diffuse expression for S100 The genetic tests for tX18 as seen in synovial sarcoma were negative and the overall histological appearance favored a diagnosis of solitary fibrous tumor To the best of our knowledge this report represents the fifth case of a solitary fibrous tumor primarily occurring in the adrenal gland The differential diagnoses of this neoplasm in our case and a brief summary of solitary fibrous tumor primarily involving the various endocrine organs are presentedThe authors would like to thank Associate Professor Manuel SaltoTellez and staff of the Diagnostic Molecular Oncology Center Department of Pathology National University Hospital Singapore for the performance and interpretation of RT–PCR and FISH studies on the tumor

Keywords: