Authors: P Adrian Evans Matthew Lawrence R H Keith Morris Naresh Thirumalai Roger Munro Lisa Wakeman Andrew Beddel P Rhodri Williams Matthew Barrow Daniel Curtis M Rowan Brown Karl Hawkins
Publish Date: 2010/07/25
Volume: 49, Issue: 9, Pages: 901-908
Abstract
This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified heparinised samples of healthy coagulating blood Heparin prolongs the onset of clot formation and has a significant effect on the microstructure of the clot which is eventually formed The results demonstrate the potential of this rheometrical technique as a new tool for monitoring the effect of heparin on samples of whole blood with significantly better linearity of response within the therapeutic range than another global coagulation monitoring technique thromboelastography which has previously been used
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