Journal Title
Title of Journal: J Artif Organs
|
Abbravation: Journal of Artificial Organs
|
|
|
|
|
|
|
|
Authors: John P Harrington Hanna Wollocko
Publish Date: 2010/12/03
Volume: 13, Issue: 4, Pages: 183-188
Abstract
Hemoglobinbased oxygen carriers HBOC are being developed to provide the oxygen necessary in clinical situations when whole blood is not available The safety and effectiveness of each HBOC must be determined before clinical approval In the past several years animal studies have been conducted with zerolinked polymers to evaluate their effectiveness at delivering oxygen in vivo Studies have addressed issues associated with interstitial extravasation cerebral ischemia and blood flow resuscitation and coagulation interactions Several of the investigations reviewed are based on early preparations of zerolinked polymerized bovine hemoglobins ZLHbBv which contained a wide range of highmolecularweight polymers Recent studies using the Oxyvita product OxyVita Hb which contains a more homogenous population 97 of largemolecularweight species ~17 MDa are also included in this review
Keywords:
.
|
Other Papers In This Journal:
|