Contrastenhanced ultrasound detects perfusion def

Authors: Ahmed Alzaraa Dhya AlLeswas Wen Yuan Chung Gianpiero Gravante Morgan Bruno Kevin West Ashley Dennison David Lloyd

Publish Date: 2013/06/29

Volume: 16, Issue: 4, Pages: 475-482

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Abstract

Following transplantation areas of hypoperfusion can be associated with metabolic changes and poor organ recovery Our study evaluated contrastenhanced ultrasound CEUS agents for the detection of such areas Livers were collected from ten pigs connected to extracorporeal circuits and perfused using autologous blood After 1 and 4 h livers were scanned with an ultrasound machine following the administration of CEUS agents Biopsies from perfused and nonperfused areas were collected The entire parenchyma enhanced strongly on noncontrast ultrasound at 1 h with no perfusion defects Four hours later multiple perfusion defects manifested not evident with noncontrast ultrasound Histology confirmed nonperfused areas corresponded to ischemic zones In our model the addition of CEUS revealed perfusion defects after 4 h This might facilitate detection and characterization of perfusion defects in transplanted livers

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