Synthesis characterization and in vitro cytotoxic

Authors: T López M Alvarez R D González M J Uddin J Bustos S Arroyo A Sánchez

Publish Date: 2011/02/12

Volume: 17, Issue: 3, Pages: 573-581

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Abstract

The adverse toxicological profile of cisplatin cisdichlorodiammineplatinum II characterized by nephrotoxicity and neurotoxicity is the main factor that limit the clinical usefulness of this antineoplastic drug specifically the possibility of applying it in effective highdose regimens In order to overcome these disadvantages many efforts in the search for new drugs have been made Due to this particularity we obtained via sol–gel process Ptacac2–TiO2 NPt nanostructured materials with antitumoral activity to be used as an alternative in the treatment of cancer tumors The biocatalysts were prepared by the sol–gel route using the complex Ptacac2 Sol–gel parameters were controlled in order to obtain high platinum dispersion and particles in the nanosize range TEM FTIR N2 adsorption and XPS characterization studies of the samples were carried out In order to investigate interactions between the biocatalyst and DNA agarose gel electrophoresis was performed and we observed the formation of DNA adducts 45 minutes after contact NPt completely degraded the DNA cisplatin 120 minutes These results demonstrate that using a metal supported and dispersed over an inorganic biocompatible oxide can be effectively used in the treatment of localized tumors

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