Journal Title
Title of Journal: LO SCAL
|
Abbravation: LO SCALPELLO-OTODI Educational
|
|
|
|
|
|
|
|
Authors: M Muratore E Quarta L Quarta F Calcagnile A Grimaldi M A Orgiani A Marsilio G Rollo
Publish Date: 2011/02/22
Volume: 24, Issue: 3, Pages: 198-205
Abstract
Studies of the mechanisms of periprosthetic bone loss have led to the development of pharmacologic strategies intended to enhance bone mass recovery after surgery and consequently prevent aseptic loosening and prolong the implant survival Bisphosphonates potent antiresorptive drugs widely used in the treatment of osteoporosis and other disorders of bone metabolism were shown to be particularly effective in reducing periprosthetic bone resorption in the first year after hip and knee arthroplasty both cemented and cementless Based on these results we investigated the inhibitory effects of ibandronate on periprosthetic bone loss in a 2year study of postmenopausal women that underwent cementless total hip arthroplasty In the first 6 months both groups A treated with ibandronate 3 mg iv within five days after surgery and then with oral ibandronate 150 mg/month plus calcium and vitamin D supplementation and B treated with calcium and vitamin D supplementation only experienced bone loss though to a lesser extent in group A After 12 months group A showed a remarkable BMD recovery that was statistically significant versus baseline values about +1 74 of global BMD and most evident in region R1 +3 81 and R2 +4 12 in group B on the contrary BMD values were unchanged compared with those at 6 months postsurgery Quality of life scores also showed a greater improvement in group A both at 6 and 12 months after surgery likely because of the painreducing effects of ibandronate treatment
Keywords:
.
|
Other Papers In This Journal:
|