Authors: Morikatsu Yoshida Shinya Shiraishi Fumi Sakaguchi Daisuke Utsunomiya Kuniyuki Tashiro Seiji Tomiguchi Hirohisa Okabe Toru Beppu Hideo Baba Yasuyuki Yamashita
Publish Date: 2012/04/12
Volume: 30, Issue: 5, Pages: 435-441
Abstract
We compared quantitative indices estimated by use of technetium99m galactosyl human serum albumin 99mTcGSA singlephoton emission computed tomography SPECT/computed tomography CT fused imaging and hepatic fibrosis in patients with chronic liver diseaseOn the basis of pathological findings we divided 161 patients into nonsevere and severe fibrosis groups n = 81 and n = 80 respectively We measured 2 indices by 99mTcGSA SPECT/CT fused imaging liver uptake value LUV = radioactivity whole liver/radioactivity injected × 100/body surface area and functional liver index FLI = radioactivity hepatocytes/radioactivity injected × 100/liver volume We compared these indices with biochemical and histopathological resultsUnivariate and multivariate analyses showed that FLI LUV LHL15 and prothrombin time were significant independent predictors of severe fibrosis On the basis of receiver operating characteristics analysis the areas under curve values of FLI LUV LHL15 and prothrombin time for predicting severe fibrosis were 083 073 069 and 068 respectively Using an FLI value of 0053 it was possible to predict severe fibrosis with 65 sensitivity 88 specificity and 76 accuracy
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