Jaeumganghwatang a traditional herbal formula in

Authors: In Sik Shin Mee Young Lee Hye Sun Lim Chang Seob Seo Hye Kyung Ha HyeunKyoo Shin

Publish Date: 2012/04/30

Volume: 55, Issue: 2, Pages: 205-212

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Abstract

Benign prostate hyperplasia BPH is the most common proliferative disorder affecting older men and results in prostate enlargement and lowered urinary tract symptoms Jaeumganghwatang JGT an oriental traditional herbal formula has been used in China Ziyinjianghuotang in Chinese Japan Jiinkokato in Japanese and Korea for many years Effects of JGT on prostate dihydrotestosterone DHT level and prostatic hyperplasia were investigated using a rat model in which BPH was induced using testosterone propionate TP Rats were divided into five groups One group was used as a normal and four groups received subcutaneous injections of TP for 4 weeks to induce BPH JGT 200 or 400 mg/kg was administered daily for 4 weeks by oral gavage concurrently with TP injections and rats were sacrificed at scheduled times Prostates were weighed and histopathologic examination was conducted DHT levels in serum and the prostate were measured and the expression of proliferating cell nuclear antigen PCNA protein was investigated using Western blotting BPH animals showed increases in absolute and relative weights of the prostate levels of DHT in serum and the prostate and expression of PCNA in the prostate whereas JGTtreated animals showed significant reductions in these indices compared with the BPH animals Administration of JGT attenuated TPinduced epithelial hyperplasia These findings indicate that JGT inhibits the development of BPH an effect closely associated with a reduction in DHT level

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