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Title of Journal: Arch Orthop Trauma Surg

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Abbravation: Archives of Orthopaedic and Trauma Surgery

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Springer-Verlag

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DOI

10.1002/bbpc.19550590621

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1434-3916

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Axially vascularized bone substitutes a systemati

Authors: A M Eweida A S Nabawi H A Elhammady M K Marei M R Khalil M S Shawky A Arkudas J P Beier F Unglaub U Kneser R E Horch
Publish Date: 2012/05/27
Volume: 132, Issue: 9, Pages: 1353-1362
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Abstract

The creation of axially vascularized bone substitutes AVBS has been successfully demonstrated in several animal models One prototypical indication is bone replacement in patients with previously irradiated defect sites such as in the mandibular region The downside of current clinical practice when free fibular or scapular grafts are used is the creation of significant donor site morbidityBased on our previous experiments we extended the creation of an arteriovenous loop to generate vascularized bone substitutes to a new defect model in the goat mandibula In this report we review the literature regarding different models for axially vascularized bone substitutes and present a novel model demonstrating the feasibility of combining this model with synthetic porous scaffold materials and biological tissue adhesives to grow cells and tissueThe mandibular reconstruction study was funded by a research grant from the University of Alexandria Alexandria University Research Enhancement Program Alex REP code HLTH09 The authors would like to acknowledge with great appreciation the team of Abou Elnaga Laboratories in Alexandria namely Dr Sahdy Foad for help with the PRP protocol standardization The animal experiments were approved by the ethics committee of the University of Alexandria and complied with the current laws of the local governmental authorities

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