Journal Title
Title of Journal: Brain Struct Funct
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Abbravation: Brain Structure and Function
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Publisher
Springer-Verlag
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Authors: Gila Z Reckess Callie Beck Dunn Russell M Bauer Christiana M Leonard
Publish Date: 2012/06/29
Volume: 218, Issue: 4, Pages: 889-901
Abstract
The three anterior temporobasal aTB sulci which are the collateral rhinal and occipitotemporal sulci contribute to the morphology of memoryrelated structures and are important landmarks for neuroimaging Prevalence of interconnections among these sulci may distinguish healthy adults and individuals with memoryrelated disorders Kim et al Neurology 702159–2165 2008 Zhan et al Hum Brain Mapp 30874–882 2009 However methods for quantifying the existence and nature of such connections are vague and varied and normative frequencies are inconsistent across studies Therefore the goals of the current study are twofold 1 to develop a reliable method of identifying aTB sulci and their interconnections based on surface renderings generated from serial magnetic resonance images MRIs This protocol includes training materials and a rating log see supplementary materials that can be disseminated and applied by other researchers 2 To determine the prevalence of interconnections among the three aTB sulci in a large sample of healthy adults 200 undergraduate students which can be used as normative data for future comparison with clinical samples Notably the resulting protocol called the Sulcal Classification Rating Protocol for anterior Temporobasal sulci distinguishes “clear” from “ambiguous” connections When only clear connections are included our prevalence rates are consistent with postmortem findings of Ono et al Atlas of the Cerebral Sulci Thieme Medical Publishers Inc New York 1990 when both clear and ambiguous connections are counted as a connection our results largely replicate MRIbased findings eg Kim et al Neurology 702159–2165 2008 We propose that systematic variations in rater classification of ambiguous connections could explain discrepancies in the literatureThis research was supported by an NIH grant DC006957 to Christine Chiarello by the McKnight Brain Institute and by a 2010 American Psychological Association Dissertation Award presented to Gila Z Reckess We would also like to thank Stephen Towler MS for assistance with data processing and Jordan Robson for serving as a rater for round 1
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