Journal Title
Title of Journal: Brain Struct Funct
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Abbravation: Brain Structure and Function
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Publisher
Springer Berlin Heidelberg
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Authors: Claudia S Barz Thomas Bessaih Ted Abel Dirk Feldmeyer Diego Contreras
Publish Date: 2015/12/31
Volume: 221, Issue: 9, Pages: 4383-4398
Abstract
To reveal the neuronal underpinnings of sensory processing deficits in patients with schizophrenia previous studies have investigated brain activity in response to sustained sensory stimulation at various frequencies This paradigm evoked neural activity at the stimulation frequency and harmonics thereof During visual and auditory stimulation that elicited enhanced or ‘resonant’ responses in healthy controls patients with schizophrenia displayed reduced activity The present study sought to elucidate the cellular basis of diseaserelated deficits in sensory resonance properties using mice heterozygous for the schizophrenia susceptibility gene Neuregulin 1 NRG1 We applied repetitive whisker stimulation at 1–15 Hz a range relevant to whisking behavior in mice and measured cellular activity in the primary somatosensory cortex At frequencies where control mice displayed enhancements in measures of response magnitude and precision NRG1 +/− mutants showed reductions Our results demonstrate for the first time a link between a mutation of a schizophrenia risk gene and altered neuronal resonance properties in sensory cortexWe would like to thank Steve Siegel and Ted Brodkin University of Pennsylvania for kindly providing NRG1 +/− mutants and WT mice We also thank members of the Contreras lab for useful discussions This work was supported by the IRTG 1328 Schizophrenia and Autism of the German Research Foundation Deutsche Forschungsgemeinschaft DFG C Barz the Interdisciplinary Center for Clinical Research IZKF Aachen within the Faculty of Medicine at the RWTH Aachen University C Barz the postdoctoral fellowship of the Fondation pour la Recherche Medicale SPE20070709864 T Bessaih the Barrel Cortex Function BaCoFun research group of the DFG D Feldmeyer the Helmholtz association D Feldmeyer as well as the National Institute of Health NIH Grants MH064045 T Abel P50MH096891 T Abel and R Gur PI and R01 EY020765 D Contreras
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