Journal Title
Title of Journal: Proc Natl Acad Sci India Sect B Biol Sci
|
Abbravation: Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
|
Publisher
Springer-Verlag
|
|
|
|
|
|
Authors: Manu D Tiwari Jayesh R Bellare
Publish Date: 2012/09/15
Volume: 82, Issue: 1, Pages: 37-58
Abstract
Polymeric nanoparticulate systems have garnered wide interest as vehicles for intracellular reporter agents and anticancer drugs in anticancer gene therapy and in reducing the adverse toxic effects of metal nanoparticles These wide ranging applications have been possible due to a favourable blend of polymer properties such as facile chemistry diverse synthesis options and amenability towards functionalization An array of polymeric nanosystems have been developed which exhibit better encapsulation higher bioavailability and controlled release of therapeutic agents In this review we discuss strategies for synthesizing tailoring and targeting polymeric nanoparticles schemes for reducing metal nanoparticle toxicity by using polymers and recent aspects of internalization and biodistribution of nanoparticulate systems with reference to cancer We also present the recent clinical status of certain key nanoparticulate anticancer drug and gene formulations
Keywords:
.
|
Other Papers In This Journal:
|