Authors: Yeruva Madhu Reddy Dhssraj Singh Darbhamulla Nagarajan Jayasree Pillarisetti Mazda Biria Hemant Boolani Martin Emert Vineela Chikkam Kay Ryschon James Vacek Sudha Bommana Donita Atkins Atul Verma Mojtaba Olyaee Buddhadeb Dawn Dhanunjaya Lakkireddy
Publish Date: 2013/06/06
Volume: 37, Issue: 3, Pages: 259-265
Abstract
An association between atrial fibrillation AF and gastroesophageal reflux disease GERD and/or irritable bowel syndrome IBS is increasingly being identified yet the role of radiofrequency catheter ablation RFA of AF has not been systematically evaluated in these patient populationsWe performed a prospective matched case–control study of AF patients with GERD and/or IBS who underwent RFA for AF in two centers in North America AF patients with GERD and/or IBS gastrointestinal GI group were matched by age gender and type of AF at each of the centers with an equal number of AF patients without GERD or IBS nonGI groupSixty patients were included in the study with 30 in each group Mean age of the population was 45 years with 14 47 males and 21 87 patients with paroxysmal AF in each group More patients in the GI group had identifiable GI triggers for AF episodes During RFA more patients in the GI group had a “vagal response” compared to nonGI group 60 vs 13 p 0001 Left atrial scar as identified by electroanatomical mapping was more common in patients in the nonGI group compared to the GI group 57 vs 27 p = 0018 At 1year followup 56 93 of the patients were free from AF with no difference between both groupsYeruva Madhu Reddy Dhssraj Singh Darbhamulla Nagarajan Jayasree Pillarisetti Mazda Biria Hemant Boolani Martin Emert Vineela Chikkam Kay Ryschon James Vacek Sudha Bommana Donita Atkins Atul Verma Mojtaba Olayee and Buddhadeb Dawn have no conflicts of interest to declare Dhanunjaya Lakkireddy received a modest speaker’s honorarium from Boehringer Ingelheim Janssen and St Jude Medical
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