Glucoseinduced cell signaling in the pathogenesis

Authors: Rokhsana Mortuza Subrata Chakrabarti

Publish Date: 2013/02/21

Volume: 19, Issue: 1, Pages: 75-86

PDF Link

Abstract

Chronic diabetic complications affect multiple organ systems and lead to significant morbidity and mortality in the diabetic population Diabetic cardiomyopathy is a major etiologic factor causing heart failure Dysfunction of both vascular endothelial cells and cardiomyocytes contributes in the pathogenesis of diabetic cardiomyopathy Hyperglycemia has been identified as the key determinant in the development of several chronic diabetic complications Hyperglycemia leads to oxidative stress and several other abnormalities causing changes in cellular signaling These diabetesmediated biochemical anomalies show crossinteraction and complex interplay Such changes also cause alteration of transcriptional and posttranscriptional machinery causing altered production of vasoactive and cardioactive factors In this review we will highlight some of the important signaling changes leading to diabetic cardiomyopathy and discuss possible potential therapeutic remedies

Keywords: