Skeletal muscle bioenergetics in aging and heart f

Authors: Sophia Z Liu David J Marcinek

Publish Date: 2016/11/05

Volume: 22, Issue: 2, Pages: 167-178

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Abstract

Changes in mitochondrial capacity and quality play a critical role in skeletal and cardiac muscle dysfunction In vivo measurements of mitochondrial capacity provide a clear link between physical activity and mitochondrial function in aging and heart failure although the cause and effect relationship remains unclear Agerelated decline in mitochondrial quality leads to mitochondrial defects that affect redox calcium and energysensitive signaling by altering the cellular environment that can result in skeletal muscle dysfunction independent of reduced mitochondrial capacity This reduced mitochondrial quality with age is also likely to sensitize skeletal muscle mitochondria to elevated angiotensin or betaadrenergic signaling associated with heart failure This synergy between aging and heart failure could further disrupt cell energy and redox homeostasis and contribute to exercise intolerance in this patient population Therefore the interaction between aging and heart failure particularly with respect to mitochondrial dysfunction should be a consideration when developing strategies to improve quality of life in heart failure patients Given the central role of the mitochondria in skeletal and cardiac muscle dysfunction mitochondrial quality may provide a common link for targeted interventions in these populations

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