Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Am Soc Mass Spectrom

Search In Journal Title:

Abbravation: Journal of The American Society for Mass Spectrometry

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1016/j.archger.2016.06.019

Search In DOI:

ISSN

1879-1123

Search In ISSN:
Search In Title Of Papers:

Matrix Assisted Ionization in Vacuum a Sensitive

Authors: Sarah Trimpin Ellen D Inutan
Publish Date: 2013/03/23
Volume: 24, Issue: 5, Pages: 722-732
PDF Link

Abstract

An astonishingly simple new method to produce gasphase ions of small molecules as well as proteins from the solid state under cold vacuum conditions is described This matrix assisted ionization vacuum MAIV mass spectrometry MS method produces multiply charged ions similar to those that typify electrospray ionization ESI and uses sample preparation methods that are nearly identical to matrixassisted laser desorption/ionization MALDI Unlike these established methods MAIV does not require a laser or voltage for ionization and unlike the recently introduced matrix assisted ionization inlet method does not require added heat MAIVMS requires only introduction of a crystalline mixture of the analyte incorporated with a suitable small molecule matrix compound such as 3nitrobenzonitrile directly to the vacuum of the mass spectrometer Vacuum intermediate pressure MALDI sources and modified ESI sources successfully produce ions for analysis by MS with this method As in ESIMS ion formation is continuous and without a laser little chemical background is observed MAIV operating from a surface offers the possibility of significantly improved sensitivity relative to atmospheric pressure ionization because ions are produced in the vacuum region of the mass spectrometer eliminating losses associated with ion transfer from atmospheric pressure to vacuum Mechanistic aspects and potential applications for this new ionization method are discussedNSF CAREER 0955975 ASMS Research Award Waters Co DuPont Young Professor Award Eli Lilly Young Investigator Award in Analytical Chemistry Waters Co COI program and Schaap Faculty Scholar to ST and Schaap Graduate Fellow to EDI are acknowledged The authors are grateful for Professor Hendrickson WSU and Professor McEwen USP for valuable feedback on this manuscript


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Distonic Ions: Editorial
  2. On the Efficiency of NHS Ester Cross-Linkers for Stabilizing Integral Membrane Protein Complexes
  3. Dynamic Interchanging Native States of Lymphotactin Examined by SNAPP-MS
  4. Quantitative Assessment of Protein Structural Models by Comparison of H/D Exchange MS Data with Exchange Behavior Accurately Predicted by DXCOREX
  5. Reflections on Charge State Distributions, Protein Structure, and the Mystical Mechanism of Electrospray Ionization
  6. CYCLONE—A Utility for De Novo Sequencing of Microbial Cyclic Peptides
  7. Mass Spectrometry-Based Quantification of Pseudouridine in RNA
  8. Statistical Examination of the a and a + 1 Fragment Ions from 193 nm Ultraviolet Photodissociation Reveals Local Hydrogen Bonding Interactions
  9. Perspective on Electrospray Ionization and Its Relation to Electrochemistry
  10. Untargeted Metabolomics Strategies—Challenges and Emerging Directions
  11. Development of a Magnetic Microbead Affinity Selection Screen (MagMASS) Using Mass Spectrometry for Ligands to the Retinoid X Receptor-α
  12. Structural Investigation of Protonated Azidothymidine and Protonated Dimer
  13. Application of Probe Electrospray Ionization Mass Spectrometry (PESI-MS) to Clinical Diagnosis: Solvent Effect on Lipid Analysis
  14. Ion-Molecule Clustering in Differential Mobility Spectrometry: Lessons Learned from Tetraalkylammonium Cations and their Isomers
  15. Charge Detection Mass Spectrometry for Single Ions with an Uncertainty in the Charge Measurement of 0.65 e
  16. Super-Atmospheric Pressure Electrospray Ion Source: Applied to Aqueous Solution
  17. Probing the Electron Capture Dissociation Mass Spectrometry of Phosphopeptides with Traveling Wave Ion Mobility Spectrometry and Molecular Dynamics Simulations
  18. Efficient Covalent Bond Formation in Gas-Phase Peptide–Peptide Ion Complexes with the Photoleucine Stapler
  19. Ion Trap Electric Field Characterization Using Slab Coupled Optical Fiber Sensors
  20. Picoelectrospray Ionization Mass Spectrometry Using Narrow-Bore Chemically Etched Emitters
  21. The H-Index of ‘An Approach to Correlate Tandem Mass Spectral Data of Peptides with Amino Acid Sequences in a Protein Database’
  22. Predicting Compensation Voltage for Singly-charged Ions in High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS)
  23. Native ESI Mass Spectrometry Can Help to Avoid Wrong Interpretations from Isothermal Titration Calorimetry in Difficult Situations
  24. Characterization of Tyrosine Nitration and Cysteine Nitrosylation Modifications by Metastable Atom-Activation Dissociation Mass Spectrometry
  25. Deconstructing Desorption Electrospray Ionization: Independent Optimization of Desorption and Ionization by Spray Desorption Collection
  26. Localization of Post-Translational Modifications in Peptide Mixtures via High-Resolution Differential Ion Mobility Separations Followed by Electron Transfer Dissociation
  27. MALDI Mass Spectrometric Imaging of Lipids in Rat Brain Injury Models
  28. High Production of Small Organic Dicarboxylate Dianions by DESI and ESI
  29. Automated Lipid A Structure Assignment from Hierarchical Tandem Mass Spectrometry Data
  30. Automated Lipid A Structure Assignment from Hierarchical Tandem Mass Spectrometry Data
  31. Transitioning from Targeted to Comprehensive Mass Spectrometry Using Genetic Algorithms

Search Result: