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Title of Journal: Aesth Plast Surg

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Abbravation: Aesthetic Plastic Surgery

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Springer US

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DOI

10.1007/s10409-015-0510-x

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1432-5241

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Mast Cells in the Periprosthetic Breast Capsule

Authors: Jacqueline Brazin Stephanie Malliaris Brittany Groh Babak Mehrara David Hidalgo David Otterburn Randi B Silver Jason A Spector
Publish Date: 2014/05/09
Volume: 38, Issue: 3, Pages: 592-601
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Abstract

Symptomatic capsular contracture occurs in about 10  of primary breast augmentations and in more than double that rate in reconstruction after mastectomy especially in the setting of radiation Mast cells traditionally associated with immune response and inflammation secrete profibrotic mediators and may play a role in capsule formation and contracture We analyzed the mast cell and fibroblast populations in breast capsule tissue from patients who underwent capsular excisionCapsule tissue was collected from patients who underwent exchange of tissue expanders for permanent implants revision of reconstruction or revision augmentation Breast capsule tissues were prepared for histological analyses of mast cells fibroblasts and collagen Mast cells and fibroblasts were isolated from capsule tissue and screened for mediators and receptor expressionIn breast capsule tissue the average numbers of mast cells and fibroblasts were 9 ± 1/mm2 and 33 ± 10/mm2 respectively There were significantly more mast cells on the posterior side than on the anterior side of the capsule tissue 12 ± 2 vs 6 ± 1/mm2 p  001 Baker grade IV capsules had an increased number of fibroblasts compared to Baker grade I capsules 93 ± 9 vs 40 ± 19/mm2 p  0001 In breast capsule tissue mast cells contained renin histamine and TGFβ and their respective receptors AT1R H1R and TGFβRI were expressed by fibroblastsThese data indicate that within breast capsule tissue mast cells contain mediators that may activate neighboring fibroblasts Understanding the role of mast cells in pathologic periprosthetic breast capsule formation may lead to novel therapies to prevent and treat capsular contractureThis journal requires that authors assign a level of evidence to each submission to which EvidenceBased Medicine rankings are applicable This excludes Review Articles Book Reviews and manuscripts that concern Basic Science Animal Studies Cadaver Studies and Experimental Studies For a full description of these EvidenceBased Medicine ratings please refer to the Table of Contents or the online Instructions to Authors http//wwwspringercom/00266

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Other Papers In This Journal:
  1. DIEP Flap Donor Site Versus Elective Abdominoplasty Short-term Complication Rates: A Meta-analysis
  2. Autologous Fat Grafting in the Breast: Critical Points and Technique Improvements
  3. Actions and Comparative Efficacy of Phosphatidylcholine Formulation and Isolated Sodium Deoxycholate for Different Cell Types
  4. Umbilical Reinsertion in Abdominoplasty: Technique Using Deepithelialized Skin Flaps
  5. Effect of Aesthetic Rhinoplasty on Respiratory Functions
  6. An Unexpected Otoplasty Complication: Temporal Nerve Paresis
  7. Techniques for the Optimization of Facial and Nonfacial Volumization with Injectable Poly- l -lactic Acid
  8. The Use of Metatarsal Bone Grafts in the Treatment of Saddle Nose Deformities
  9. A Triangular Suture to Simplify Reduction Mammaplasty
  10. Management and Aesthetic Results of Support Grafts in Saddle Nose Surgery
  11. The Universal Serial Bus Endoscope: Design and Initial Clinical Experience
  12. Gavello's Procedure: An Old Earlobe Reconstruction Method, Revisited and Touched Up
  13. Is Breast Augmentation Using Hyaluronic Acid Safe?
  14. Facing the Worst Risk: Confronting the Dorsal Nasal Artery, Implication for Non-surgical Procedures of Nasal Augmentation
  15. Why Is Lip Augmentation with Autologous Fat Injection Less Effective in the Vermilion Border?
  16. The Breast Implant Rupture Warranty: What Is It Really Worth?
  17. Rotation Mastopexy: An Anatomical Approach
  18. Lipoma with Bone and Cartilage Components in the Left Axilla of a Middle-aged Woman
  19. The Spreader-Splay Graft Combination: A Treatment Approach for the Osseocartilaginous Vault Deformities Following Rhinoplasty
  20. Temperament and Character Traits of Women Admitted for Breast Reduction and Comparison with Body Perception
  21. The Average Indian Female Nose
  22. Foreign Body Removal and Immediate Nasal Reconstruction with Superficial Temporal Fascia
  23. Inferior Pedicle Autoaugmentation Mastopexy After Breast Implant Removal
  24. A Comprehensive Screening, Education, and Training Tool for the Psychological Assessment of Patients Seeking Aesthetic Surgery: “DESIRABLE OP?”
  25. Laser Lipolysis With 924- and 975-nm Laser Diodes in the Lower Extremities
  26. A Case of Life-Threatening Sepsis After Breast Augmentation by Fat Injection
  27. Invited Commentary for “Preoperative Magnetic Resonance Imaging-Based Breast Volumetry for Immediate Breast Reconstruction”
  28. Feminization of the Forehead in a Transgender: Frontal Sinus Reshaping Combined with Brow Lift and Hairline Lowering
  29. Aesthetic Shoulder Augmentation with Silicone Implants
  30. Aesthetic Shoulder Augmentation with Silicone Implants
  31. Determination of Lower Limb Microvasculature by Intrafemoral Arterial Injection Using Computed Tomography-Assisted Angiography
  32. Columella Lengthening by a Vascularized Preauricular Flap
  33. Allogenous Cartilage Graft Versus Autogenous Cartilage Graft in Augmentation Rhinoplasty: A Decade of Clinical Experience
  34. The Correction of Alar–Columella Web Deformities in Unilateral Cleft-Lip Nasal Deformities with Web Graft Technique
  35. Vaginal Labiaplasty: Defense of the Simple “Clip and Snip” and a New Classification System
  36. A New Procedure for Correction of Severe Inverted Nipple with Two Triangular Areolar Dermofibrous Flaps
  37. Early Intervention with Highly Condensed Adipose-Derived Stem Cells for Complicated Wounds Following Filler Injections
  38. Biologic Behavior of Hydroxyapatite Used in Facial Augmentation
  39. Evaluation of Results From Reduction Mammaplasty: Relief of Symptoms and Patient Satisfaction
  40. Infections of Breast Implants in Aesthetic Breast Augmentations: A Single-Center Review of 3,002 Patients
  41. The True Incidence of Near-Term Postoperative Complications in Prosthetic Breast Reconstruction Utilizing Human Acellular Dermal Matrices: A Meta-Analysis
  42. Autologous Fat Injection for Soft Tissue Augmentation in the Face: A Safe Procedure?
  43. No-Touch Technique for Autologous Fat Harvesting
  44. Erratum to: Peter Bela Fodor, M.D., F.A.C.S., Medical Editor, Elizabeth Sadati Bernard, Editorial Consultant, Bill Winn, B.S., M.S., F.A.M.I., Medical Illustrator, and Rex M. Oppenheimer, Coordinating Author: Be Your Best: A Comprehensive Guide to Aesthetic Plastic Surgery
  45. Gluteal Reduction: A New Technique With Tightening, Lifting, and Reshaping Effects on the Buttocks
  46. Breast Implant Capsule Flaps and Grafts: A Review of the Literature
  47. Augmentation Gluteoplasty: The XYZ Method
  48. The Double Pocket Technique: Aesthetic Breast Augmentation
  49. Our Experience with the Triple-V Transareolar Incision for Augmentation Mammaplasty
  50. A Systematic Review of Patient-Reported Outcome Measures Following Transsexual Surgery
  51. Doppler Ultrasound Evaluation of Facial Transverse and Infraorbital Arteries: Influence of Smoking and Aging Process
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