Early Intervention with Highly Condensed AdiposeD

Authors: Joo Hyun Kim Seong Hoon Park Byeong Ho Lee Hii Sun Jeong Hyun Jin Yang In Suck Suh

Publish Date: 2016/04/21

Volume: 40, Issue: 3, Pages: 428-434

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Abstract

A rise in cosmetic procedures has seen the use of fillers become more prevalent Complications resulting from use of fillers have prompted introduction of various medical and surgical interventions Recently stem cell therapies have become more widely used as a new treatment option for tissue repair and regenerationWe utilized adiposederived stem cells ASCs for tissue regeneration in patients with fillerrelated complications such as necrosis All 12 patients were treated with ASCs and some patients had additional treatment After relief of symptoms wound surface area was compared in terms of pixel numbers and scar condition was evaluated using the Vancouver Scar Scale VSSIn general we achieved satisfactory resolution of fillerrelated complications in a short period of time without serious side effects The average number of days from stem cell treatment to symptom relief was 73 days The proportion of wound surface area from photographic record was 439  before treatment decreasing considerably to 101  following treatment Last the VSS showed almost all patients scored below 3 with two patients receiving scores of 7 and 8 the average score was 278 range from 0 to 8ASCs are a new treatment option for postfiller injection wounds such as necrosis Using stem cells we were able to obtain satisfactory results in a short period of time without complications requiring surgical procedures We suggest stem cell injections could be used as the first option for treatment of complications from filler injectionsUse of soft tissue fillers to restore volume to depressed areas of skin for maintenance of a youthful appearance has been widespread in recent years Such use is very popular because of its simplicity low invasiveness and procedure reversibility as well as a relatively safe profile However as use of fillers has increased so too has the number of reported complications These complications such as vascular compromise and skin necrosis are often significant and permanentUse of stem cells with regenerative potential such as embryonic or mesenchymal stem cells has recently emerged as a new form of therapy for wound management Stem cells are multipotent and possess the ability to selfrenew They are thought to help heal wounds by stimulating angiogenic processes and secreting angiogenic factors however the exact mechanisms remain unknown A newer type of adult stem cell derived from adipose cells within fat tissue was discovered at the end of the 20th century These stem cells are known as adiposederived stem cells ASCs 1We have observed many patients with complications following the use of soft tissue fillers Despite attempts at remediation with various treatments including dressing with various materials surgical debridement skin grafts and local flaps unsightly skin loss scarring and asymmetry still occurred Therefore in an effort to maximize rapid recovery and minimize adverse sequelae we examined the use of stem cell therapy at an early stage of wound development in patients who had received filler injections

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