Journal Title
Title of Journal: Transl Stroke Res
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Abbravation: Translational Stroke Research
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Authors: Kentaro Mori
Publish Date: 2014/07/03
Volume: 5, Issue: 6, Pages: 647-652
Abstract
Several animal subarachnoid hemorrhage SAH models have been proposed to study the etiology and treatment for cerebral vasospasm We describe the experimental procedures of a canine doublehemorrhage model of SAH and discuss the pathophysiological parameters and occurrence of angiographic delayed cerebral vasospasm using magnetic resonance MR imaging and digital subtraction angiography Autologous blood was injected twice on days 1 and 3 into the cerebellomedullary cistern of 36 female beagles All animals showed delayed angiographic vasospasm in the vertebrobasilar arteries on day 7 The degree of vasospasm was 29–42 of the arterial diameter However this model showed no symptomatic vasospasm or ischemic changes detected by MR imaging This animal model can produce reproducible delayed vasospasm without detectable cerebral infarction on MR imaging This model allows evaluation of the effect of treatment on delayed vasospasm in the same animals The canine doublehemorrhage model of SAH is suitable for the quantitative and chronological study of delayed angiographic vasospasm but not for investigating early brain injury and delayed cerebral ischemiaAll animal experiments included in this review article were carried out in accordance with the Institutional Guidelines and the Roles of Animal Experimentation and the Guide for the Care and Use of Laboratory Animals of Juntendo University Shizuoka Hospital Izunokuni Shizuoka Japan
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