Authors: Sibel Demirel Ozge Yanik Figen Batioglu Emin Ozmert
Publish Date: 2014/07/31
Volume: 35, Issue: 4, Pages: 541-547
Abstract
The purpose of this study was to determine intraocular pressure IOP changes following intravitreal ranibizumab injections and to investigate the effect of preexisting glaucoma and pseudophakia Two hundred and two eyes of 175 patients who received repeated intravitreal ranibizumab injections were included in this study IOP measurements were obtained at both 30 min and 24 h after each injection IOP changes after the first third sixth ninth and twelfth injections were analyzed Data gotten from subgroups with preexisting glaucoma and pseudophakia were also analyzed The mean number of injections was 481 ± 27 range 3–18 while the mean IOP prior to the first intravitreal ranibizumab injection was 1511 ± 28 9–25 mmHg At the last visit IOP was 1466 ± 28 9–22 mmHg There was no cumulative increase in IOP at either 30 min or 24 h values throughout repeated injections Pseudophakic patients had significantly lower mean IOP values at 30 min after all injections except for twelfth The number of eyes with an IOP higher than 21 mm Hg and the mean IOP values were significantly higher in patients with preexisting glaucoma at 30 min after the first and third injections Pseudophakic eyes are less prone to immediate IOP spikes than phakic eyes Preexisting glaucoma may be a potential risk factor for uncontrolled IOP spikes immediately after intravitreal injection nonetheless this effect is usually transient and does not cause longterm problems Also ranibizumab injections can be administered safely under close monitoring
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