Authors: Eray Atalay Nevbahar Tamçelik Ceyhun Arici Ahmet Özkök Metin Dastan
Publish Date: 2014/03/31
Volume: 35, Issue: 2, Pages: 215-219
Abstract
To evaluate the change in intraocular pressure IOP after pharmacologic dilation in eyes with primary open angle glaucoma POAG pseudoexfoliation glaucoma PXG and eyes of normal subjects This crosssectional study was conducted in a university hospitalbased setting Patients with PXG POAG and normal subjects were consecutively selected and included in the study Of the 125 eyes of 125 subjects 46 25 female had PXG 42 29 female had POAG and 37 20 female belonged to the control group Pharmacologic dilation procedure consisted of instillation of topical phenylephrine HCL 10 followed 5 min by tropicamide 1 Studied variables were pre and postdilation IOP and also baseline measurements of anterior chamber angle central corneal thickness and pupillary diameter by Pentacam HR Oculus Wetzlar Germany Clinically significant IOP change was defined as a change of ≥2 mmHg from baseline Randomly selected single eye of each patient was included in the analysis The mean prepostdilation IOP of eyes with PXG and POAG was 1739 ± 3891754 ± 398 and 1592 ± 2371607 ± 289 mmHg respectively The difference between the pre and postdilation IOP of eyes with PXG and POAG was not statistically significant The eyes of control subjects however had a statistically significant reduction of IOP from 1424 ± 288 to 1354 ± 294 mmHg P = 0005 283 13/46 of eyes with PXG 167 7/42 of eyes with POAG and 27 1/37 of control eyes showed a clinically significant IOP elevation from baseline after the dilation In this study glaucoma patients proportionally experienced a higher rate of clinically significant IOP elevation after pupillary dilation when compared to normal subjects
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