Authors: Yasunori Iwasaki Shinzo Takamori Masahiro Mitsuoka Masaki Kashihara Tatsuya Nishi Daigo Murakami Ryoichi Matsumoto Hiroharu Mifune Yuji Tajiri Yoshito Akagi
Publish Date: 2016/05/12
Volume: 64, Issue: 7, Pages: 409-413
Abstract
Models of malignant pleuritis were produced by an intravenous injection of lung adenocarcinoma cells to male BALB/c nude mice at 6 weeks of age Two weeks after the injection either talc or saline was injected into the left thoracic cavity and the mice were further observed for 4 weeks Six weeks after the injection they were killed and the occurrence of lung cancer amount of pleural effusion and histological change of the pleural cavity were examined and compared between the two groups with or without talc administrationTalc administration caused a significant reduction in pleural effusion with no increase of pleural adhesion Talc administration resulted in marked pleural thickening compared to saline treatment The vascular architecture and its area did not differ between the two groups
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