Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Eur Spine J

Search In Journal Title:

Abbravation: European Spine Journal

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1007/bf00357711

Search In DOI:

ISSN

1432-0932

Search In ISSN:
Search In Title Of Papers:

Does type 2 diabetes mellitus promote intervertebr

Authors: Stella Maris Fabiane Kirsten J Ward James C Iatridis Frances M K Williams
Publish Date: 2016/06/06
Volume: 25, Issue: 9, Pages: 2716-2720
PDF Link

Abstract

Twin volunteers from the TwinsUK cohort having spine magnetic resonance MR scans coded for LDD and information about T2D were investigated in two ways First as a population sample and second as a cotwin case control study in twin pairs discordant for T2D Other risk factors for LDD considered were age bodymass index BMI smoking and alcoholIn 956 twin volunteers T2D had a prevalence of 66  LDD score was higher in T2D twins 149 vs 131 p = 004 but was not an independent risk factor if the influence of age and BMI were included in the model Discordant twin analysis n = 33 pairs showed no significant difference in LDD between twins having T2D and their unaffected cotwinsTwins having T2D did manifest higher LDD scores but the effect was abrogated once BMI was included in multivariable analysis showing it is not an independent risk factor for LDD The population study had 80  power at 01 significance level to detect a difference of 18 in LDD score range of 0–60 so if there is an effect of T2D on LDD it is likely to be smallLow back pain is highly prevalent in the Western world and accounts for considerable work absenteeism There is an accepted relationship between back pain and lumbar disc degeneration LDD although the strength of the association remains debated 1 2 There is some evidence that type 2 diabetes mellitus T2D is important in the aetiology of LDD T2D is reported to be associated with spinal stenosis 3 Individuals with obesity and T2D are at an increased risk of low back pain and musculoskeletal complications but the relative contributions of the two risk factors remains unclear 4 5Worldwide prevalence of diabetes mellitus in general is 9  of the population with T2D accounting for 90  of all the cases Increased bodymass index BMI is one of the most important risk factors for T2D and an epidemic of obesity is leading to increased T2D prevalence This has important implications for low back pain and disability which already represent considerable social challenges Changes in intervertebral disc physiology and structure in diabetes are well documented in animal models 6 7 and in vitro studies of disc cells in high glucose media support a deleterious effect Increased BMI is also a wellrecognised risk factor for LDD 5 8 although the strength of this association has been disputed 9A population based study of LDD epidemiology accounting for T2D has not yet been described perhaps because of the considerable heritability of LDD 70  of the phenotypic variance in LDD is genetic This means that there is considerable genetic influence on LDD phenotype variation so large population samples are required for adequate power The inherent genetic matching of twin pairs provides a powerful study design and in TwinsUK an unselected sample of twins have had LDD determined using the gold standard method of T2weighted MR scansTwinsUK is a large registry of samesex twins containing both monozygotic MZ and dizygotic DZ same sex twin pairs It contains extensive genotype and phenotype data obtained at clinical visits and by questionnaire TwinsUK has contributed to the understanding of a wide variety of traits and diseases including musculoskeletal disease and LDD and they are similar to the general singleton population 2 10 11 We examined the association between LDD and T2D status of twins having baseline lumbar spine MRI scans 10 as a population sample In addition we considered the twin pairs in a T2D discordant cotwin design using the inherent matching within twin pairs for age sex genetic factors 100  in monozygotic MZ and on average 50  in dizygotic DZ twin pairs and other measured and unmeasured confounders MR scans had been scored for LDD and the summary measure of disc degeneration LDD score was made considering four features disc height disc signal intensity disc bulge and anterior osteophytes each coded 0–3 and summed over five discs 10 T2D was defined by the serum fasting glucose level ≥7 mmol l−1 and/or selfreport of a physician’s diagnosis of T2D on questionnaire as previously 12 Other risk factors for LDD considered were age body mass index smoking alcohol consumption and glycated haemoglobin HbA1C mmol−1 Ethics permission had been obtained from the St Thomas’ Hospital ethics committee and twins gave fully informed written consent


Keywords:

References


.
Search In Abstract Of Papers:
Other Papers In This Journal:

  1. Intraoperative spine ultrasound: application and benefits
  2. Left iliac artery injury during anterior lumbar spine surgery diagnosed by intraoperative neurophysiological monitoring
  3. Hypervascular cervical spine metastases: embolization by direct injection of Onyx-18
  4. Minimally invasive resection of extradural dumbbell tumors of thoracic spine: surgical techniques and literature review
  5. Anterior cervical fusion with interbody cage containing β-tricalcium phosphate augmented with plate fixation: a prospective randomized study with 2-year follow-up
  6. Removal of discal cyst using percutaneous working channel endoscope via transforaminal route
  7. Driving reaction time before and after surgery for lumbar disc herniation in patients with radiculopathy
  8. Thoracolumbar intramedullary subependymoma with multiple cystic formation: a case report and review
  9. Intrapiriformis lipoma: an unusual cause of piriformis syndrome
  10. Piriformis syndrome after percutaneous endoscopic lumbar discectomy via the posterolateral approach
  11. Application triangular osteosynthesis for vertical unstable sacral fractures
  12. The application of zero-profile anchored spacer in anterior cervical discectomy and fusion
  13. The Michel Benoist and Robert Mulholland yearly European Spine Journal Review: a survey of the “surgical research” articles in the European Spine Journal 2014
  14. The ipsilateral lamina–pedicle angle: can it be used to guide pedicle screw placement in the sub-axial cervical spine?
  15. Predictors for surgical complications of en bloc resections in the spine: review of 220 cases treated by the same team
  16. Skipped versus consecutive pedicle screw constructs for correction of Lenke 1 curves
  17. Cervical spondylotic myelopathy: the relevance of the spinal cord back shift after posterior multilevel decompression. A systematic review
  18. A biomechanical analysis of the self-retaining pedicle hook device in posterior spinal fixation
  19. Nonoperative treatment of active spondylolysis in elite athletes with normal X-ray findings: literature review and results of conservative treatment
  20. Lumbar spinal stenosis treatment with aperius perclid interspinous system
  21. Validity and responsiveness of the Core Outcome Measures Index (COMI) for the neck
  22. Quantitative analysis of sensory functions after lumbar discectomy using current perception threshold testing
  23. The effect of pre-vertebroplasty tumor ablation using laser-induced thermotherapy on biomechanical stability and cement fill in the metastatic spine
  24. Efficacy of antifibrinolytic agents on surgical bleeding and transfusion requirements in spine surgery: a meta-analysis
  25. Correction of pelvic obliquity in neuromuscular spinal deformities using the “T construct”: results and complications in a prospective series of 60 patients
  26. Sagittal deformities of the spine: factors influencing the outcomes and complications
  27. Simple prediction method of lumbar lordosis for planning of lumbar corrective surgery: radiological analysis in a Korean population
  28. The 100 most cited spine articles
  29. Expert’s comment concerning Grand Rounds case entitled “Minimal access bilateral transforaminal lumbar interbody fusion for high-grade isthmic spondylolisthesis” (by Nasir A. Quraishi and Y. Raja Rampersaud; doi:10.1007/s00586-012-2623-2)
  30. Publication rates: is more better?
  31. The influence of adjacent level disc disease on discectomy outcomes
  32. Letter to the Editor concerning “Efficacy of exercise therapy for the treatment of adolescent idiopathic scoliosis: a review of the literature” by Mordecai SC and Dabke HV (2012) Eur Spine J 21:382–389
  33. Management of neck pain and associated disorders: A clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration
  34. Comparison of single-level L4–L5 versus L5–S1 lumbar disc replacement: results and prognostic factors
  35. Nucleus disc arthroplasty with the NUBAC™ device: 2-year clinical experience
  36. Perioperative and short-term advantages of mini-open approach for lumbar spinal fusion
  37. What is an acceptable outcome of treatment before it begins? Methodological considerations and implications for patients with chronic low back pain
  38. Minimally-invasive technique for transforaminal lumbar interbody fusion (TLIF)
  39. What is the preclinical evidence on platelet rich plasma and intervertebral disc degeneration?
  40. Pulsed radiofrequency effects on the lumbar ganglion of the rat dorsal root: a morphological light and transmission electron microscopy study at acute stage
  41. A large tuberculosis abscess causing spinal cord compression of the cervico-thoracic region in a young child
  42. The influence of preoperative MRI findings on lumbar fusion clinical outcomes
  43. The clinical presentation of chronic whiplash and the relationship to findings of MRI fatty infiltrates in the cervical extensor musculature: a preliminary investigation
  44. The lumbar vertebral disc
  45. Effect of a novel interspinous implant on lumbar spinal range of motion
  46. Incidence of vascular complications during lateral lumbar interbody fusion: an examination of the mini-open access technique
  47. Long-term management of congenital lordoscoliosis of the thoracic spine
  48. Association between pain sensitivity in the hand and outcomes after surgery in patients with lumbar disc herniation or spinal stenosis
  49. The feasibility of inserting a C1 pedicle screw in patients with ponticulus posticus: a retrospective analysis of eleven patients
  50. Sagittal geometry of the middle and lower cervical endplates
  51. Glucocorticosteroid-induced spinal osteoporosis: scientific update on pathophysiology and treatment
  52. Accumulation of psychosocial and lifestyle factors and risk of low back pain in adolescence: a cohort study
  53. A European spine registry
  54. Evaluation of corticospinal excitability in cervical myelopathy, before and after surgery, with transcranial magnetic stimulation: a pilot study
  55. Trends analysis of rhBMP utilization in single-level posterior lumbar fusion (PLF) in the United States
  56. Safety of fluoroscopy guided percutaneous access to the thoracic spine
  57. Interest of T1 parameters for sagittal alignment evaluation of adolescent idiopathic scoliosis patients
  58. Responsiveness of the Oswestry Disability Index and the Roland Morris Disability Questionnaire in Italian subjects with sub-acute and chronic low back pain
  59. Comment on Guo et al. entitled “A prospective randomized controlled study on the treatment outcome of SpineCor brace versus rigid brace for adolescent idiopathic scoliosis with follow-up according to the SRS standardized criteria”
  60. Comparison of different operative modalities in post-traumatic syringomyelia: preliminary report
  61. Letter to the Editor concerning “Biomechanical evaluation of the Facet Wedge: a refined technique for facet fixation” by Hartensuer R. et al.; Eur Spine J (2014) 23:2321–2329
  62. AIS and spondylolisthesis
  63. Biomechanical in vitro comparison of different mono- and bisegmental anterior procedures with regard to the strategy for fracture stabilisation using minimally invasive techniques
  64. Combined intra-extracanal approach to lumbosacral disc herniations with bi-radicular involvement. Technical considerations from a surgical series of 15 cases
  65. Compliance of the L5-S1 spinal unit: a comparative study between an unconstrained and a partially constrained system
  66. Growing trend of China’s contribution to the field of spine: a 10-year survey of the literature
  67. Gender differences as an influence on patients’ satisfaction rates in spinal surgery of elderly patients
  68. Redundant nerve roots of the cauda equina in lumbar spinal canal stenosis, an MR study on 500 cases
  69. Vertebral, rib, and intraspinal anomalies in congenital scoliosis: a study on 202 Caucasians
  70. Analysis of squat and stoop dynamic liftings: muscle forces and internal spinal loads
  71. Evaluation of health-related quality of life in patients candidate for spine and other musculoskeletal surgery
  72. Percutaneous posterior-lateral lumbar interbody fusion for degenerative disc disease using a B-Twin expandable spinal spacer
  73. Effects of unisegmental disc compression on adjacent segments: an in vivo animal model
  74. Therapeutic options and results following fixed atlantoaxial rotatory dislocations
  75. Yoga and disc degenerative disease in cervical and lumbar spine: an MR imaging-based case control study
  76. Molecular phenotypes of notochordal cells purified from immature nucleus pulposus
  77. Multifidus muscle changes and clinical effects of one-level posterior lumbar interbody fusion: minimally invasive procedure versus conventional open approach
  78. De novo degenerative lumbar scoliosis: a systematic review of prognostic factors for curve progression
  79. Cross-cultural adaptation and validation of the NASS outcomes instrument in Spanish patients with low back pain
  80. Intramedullary hemangioblastomas: timing of surgery, microsurgical technique and follow-up in 23 patients
  81. Kyphectomy in myelomeningocele with a modified Dunn-McCarthy technique followed by an anterior inlayed strut graft
  82. Recovery of severe motor deficit secondary to herniated lumbar disc prolapse: is surgical intervention important? A systematic review
  83. New concept for backache: biopsychosocial pain syndrome
  84. Anatomy of large animal spines and its comparison to the human spine: a systematic review
  85. The Michel Benoist and Robert Mulholland yearly European Spine Journal Review
  86. Answer to the Letter to the Editor of T.A. Mattei concerning “Far lateral approaches (XLIF) in adult scoliosis” by P. Berjano and C. Lamartina (Eur Spine J. 2012 Jul 27. [Epub ahead of print])
  87. Preoperative transarterial embolization of vertebral metastases
  88. Neurological impairment score in lumbar spinal stenosis
  89. Spinal angiolipoma: etiology, imaging findings, classification, treatment, and prognosis
  90. Time of transition
  91. Antidepressants and the risk of abnormal bleeding during spinal surgery: a case–control study
  92. Neurological impairment score in lumbar spinal stenosis
  93. Efficacy of intraoperative direct electrical stimulation of the spinal root and measurement of distal motor latency in lumbar spinal stenosis
  94. Rupture of the spleen following thoracoscopic spine surgery in a patient with chronic pancreatitis
  95. Early changes in pulmonary function following thoracotomy for scoliosis correction: the effect of size of incision

Search Result: