Serum uric acid levels are associated with a high

Authors: Hirohito Kuwata Shintaro Okamura Yasuaki Hayashino Hitoshi Ishii Satoru Tsujii

Publish Date: 2016/02/03

Volume: 7, Issue: 4, Pages: 352-360

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Abstract

Longitudinal data from a Japanese diabetes registry including 3454 type 2 diabetes patients were obtained To assess the independent correlations between SUA and rapid CKD progression ie 30  reduction in estimated glomerular filtration rate eGFR over 2 years participants were divided into five groups based on SUA levels 50 ≥50–60 ≥60–70 ≥70–80 and ≥80 mg/dl Cox proportional hazards model adjusted for potential confounders was used for analysisAfter 2 years rapid CKD progression was recognized in 169 patients 489  who showed longer duration of type 2 diabetes 155 vs 135 years p = 0005 higher systolic blood pressure 1420 vs 1383 mmHg p = 0016 SUA 615 vs 532 mg/dl p  0001 and urinary albumin–creatinine ratio 11274 vs 1847 mg/gCr p  0001 and lower diastolic blood pressure 697 vs 728 mmHg p = 0003 Multivariate ratios for rapid CKD progression were 119 p = 0371 102 p = 0937 118 p = 0625 and 304 p = 0004 respectively for the first third fourth and fifth serum UA range groups a second group was used as a referenceWe would like to especially thank Yukari Moritsuji Yuki Fujita Noriko Nakamura and Yoko Sakamoto Department of Endocrinology Tenri Hospital for their clerical support The authors would like to thank Enago http//wwwenagojp for the English language reviewThis study was partially supported by the Manpei Suzuki Diabetes Foundation and JSPS KAKENHI grant no 25460641 however they played no role in the design conduct data collection analysis or results interpretation of the study or in the preparation review or approval of the manuscript H Ishii reports personal fees from Takeda Pharmaceutical Co Ltd personal fees from Eli Lilly Japan KK personal fees from Merck Co Inc personal fees from Astellas Pharma Inc and personal fees from Novo Nordisk Pharma Ltd outside the submitted workAll procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation institutional and national and with the Helsinki Declaration of 1964 and later versions Informed consent or a substitute for it was obtained from all patients for being included in the studyMembers of the Diabetes Distress and Care Registry at Tenri Study Group Satoru Tsujii Hirohito Kuwata Shintaro Okamura Yasuaki Hayashino Miyuki Furuya Masako Kitatani Department of Endocrinology Tenriyorozu Hospital Hitoshi Ishii Tsuyoshi Mashitani Department of Diabetology Nara Medical University Satoshi Matsunaga Department of Hematology Endocrinology and Metabolism Niigata University Faculty of Medicine Yaeko Kondo Naotaka Fujita Department of Diabetes and Clinical Nutrition Kyoto University Rei Ueda Second Department of Internal Medicine Faculty of Medicine University of the Ryukyus Rie Kurokawa Osaka Medical Center and Research Institute for Maternal and Child Health Masami Tanaka Division of Endocrinology Metabolism and Nephrology Department of Internal Medicine Keio University School of Medicine

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