Authors: Vishwakarma Pratibha Shankar Kundavi Varma R Thangam S Ramakrishnan
Publish Date: 2016/03/11
Volume: 66, Issue: 2, Pages: 598-600
Abstract
Neonatal lupus syndrome NLS is a classic model of passively acquired autoimmunity Congenital heart block CHB is a manifestation of NLS Pregnant women whose sera contain antiSjögren’s syndrome A SSA/Ro antibodies in the presence or absence of antiSSB/La antibodies have a 1–75 risk of having a child with thirddegree CHB The CHB presents as fetal bradycardia and cardiac failure ie pericardial effusion and hydrops after 16 to 24 weeks of gestationThe recurrence rate of CHB ranges from 16 to 20 in different series and the prognosis is poor About 31 of involved children die and 71 of deaths occur in the first month of life because of heart failure Sixtyseven percent of cases require pacemakers The most important treatment is preventive involving steroids immunosuppressants intravenous immunoglobulin IVIG and plasmapheresis during pregnancy before the critical period of cardiac development Treatment response of established cases is poorDr Pratibha Vishwakarma MBBS MS Obst Gynae is Post doctoral Fellow in Institute of Reproductive Medicine Women’s Health Madras Medical Mission Hospital Dr Shankar Kundavi DGO DNB MNAMS is Senior Consultant in Institute of Reproductive Medicine Women’s Health Madras Medical Mission Hospital Dr Varma R Thangam PhD FRCS FRCOG is Medical Director in Institute of Reproductive Medicine Women’s Health Madras Medical Mission Hospital Dr SRamakrishnan DM Rheumatology is Senior Consultant Appolo Hospital Chennai
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