Authors: John D Michenfelder James H Milde Thoralf M Sundt
Publish Date: 1976/05/01
Volume: 33, Issue: 5, Pages: 345-350
Abstract
• Regional cerebral ischemia was produced in 18 Java monkeys by permanent middle cerebral artery MCA occlusion All monkeys were thereafter paralyzed pancuronium bromide 005 mg/kg/hr and sedated diazepam 01 mg/kg/hr for a 48hour period Thirty minutes after MCA occlusion pentobarbital sodium anesthesia was induced in nine of the monkeys 14 mg/kg and maintained for 48 hours 7 mg/kg every two hours with continuous supportive care After 48 hours all drugs were discontinued the monkeys were observed for five days and then killed Seven of the control monkeys developed a cerebral infarction three did not survive past the 48 hours of intensive care and the other four had a notable neurologic deficit All pentobarbital monkeys survived the seven days but four had a cerebral infarction and two of these had a notable neurologic deficit These differences were statistically significant
Keywords: