Authors: Hugo W Ruediger
Publish Date: 2005/10/14
Volume: 79, Issue: 5, Pages: 343-348
Abstract
Several epidemiological and experimental studies demonstrate that combinations of carcinogens may interact in a synergistic way This has prompted speculations that modulating interactions of individual chemical carcinogens are synergistic as a rule However various combinations of chemical carcinogens have been described which interact not even additively but in an antagonistic way The aim of this review is to collect information of antagonistic interactions of occupational carcinogens obtained by epidemiologic and animal studies In addition appropriate in vitro studies with the genotoxic endpoints DNAadducts and micronuclei are included The toxicological mechanisms of antagonistic interactions although speculative in some cases are discussed
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