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Title of Journal: Int Arch Occup Environ Health

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Abbravation: International Archives of Occupational and Environmental Health

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Springer Berlin Heidelberg

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DOI

10.1007/bf02836856

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1432-1246

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Contact allergy to preservatives in patients with

Authors: Jakob Ferløv Schwensen Ulrik Fischer Friis Torkil Menné MariAnn Flyvholm Jeanne Duus Johansen
Publish Date: 2017/02/06
Volume: 90, Issue: 4, Pages: 319-333
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Abstract

A retrospective epidemiological observational analysis of data from a university hospital was conducted All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5year period 2009–2013 Information regarding the same preservatives in chemical products for occupational use ‘substances and materials’ registered in the Danish Product Register Database PROBAS was obtainedThe frequency of preservative contact allergy was 142 n = 141 in 995 patients with occupational contact dermatitis Patients with preservative contact allergy had significantly more frequently facial dermatitis 199 versus 131 and age  40 years 716 versus 458 than patients without preservative contact allergy whereas atopic dermatitis was less frequently observed 121 versus 198 Preservative contact allergy was more frequent in painters with occupational contact dermatitis as compared to nonpainters with occupational contact dermatitis p  0001 This was mainly caused by contact allergy to methylisothiazolinone and contact allergy to formaldehyde Analysis of the registered substances and materials in PROBAS revealed that preservatives occurred in several product categories eg ‘paints and varnishes’ ‘cleaning agents’ ‘cooling agents’ and ‘polishing agents’ Formaldehyde and isothiazolinones were extensively registered in PROBAS

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