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Title of Journal: Acta Neuropathol

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Abbravation: Acta Neuropathologica

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Springer-Verlag

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DOI

10.1002/bit.20731

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1432-0533

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Frequency and clinicopathological characteristics

Authors: Osamu Yokota Kuniaki Tsuchiya Seishi Terada Kenichi Oshima Hideki Ishizu Masaaki Matsushita Shigetoshi Kuroda Haruhiko Akiyama
Publish Date: 2006/04/19
Volume: 112, Issue: 1, Pages: 43-51
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Abstract

Alcoholic cerebellar degeneration ACD is a pivotal neurological complication in alcoholics However although there are a few autopsy reports and some data on its frequency it is considered very rare in Japan The aims of this study were 1 to estimate the frequency of the disease in Japanese autopsy cases and 2 to examine the clinicopathological features of symptomatic and asymptomatic cases of ACD We reviewed the records of 1509 Japanese autopsies obtained from three autopsy series in Japan and selected all 55 cases 36 with alcoholism On neuropathological reexamination ACD was confirmed in six male alcoholics 04 of all subjects 109 of all alcoholics mean age at death 593±134 years ± SD including three asymptomatic cases These frequencies were much lower than some previous Western findings but more common than that has been expected in Japan The frequencies of memory impairment and ataxia in ACD cases were significantly higher than those in alcoholics without any alcoholrelated pathologies In ACD cases loss of Purkinje cells narrowing of the width of the molecular layer and tissue rarefaction in the granular layer were observed in the anterior and superior portions of the vermis of the cerebellum In adjacent regions the Purkinje cell and molecular layers were more mildly affected The distribution of severely affected regions was more restricted in the asymptomatic cases than in the symptomatic cases This study confirmed the frequency of asymptomatic cerebellar degeneration in alcoholics suggesting that early intervention in alcoholism in the subclinical phase is important to prevent the development of cerebellar symptomsWe would like to thank Ms M Onbe Department of Neuropsychiatry Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences and Ms A Kajitani Department of Laboratory Medicine Zikei Institute of Psychiatry for collecting clinical information and Mr A Sasaki for help with the creation of the manuscript This work was supported by a grant in aid for scientific research from the Ministry of Education Culture Sports Science and Technology 14570957 and a research grant from the Zikei Institute of Psychiatry

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