Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Acta Neuropathol

Search In Journal Title:

Abbravation: Acta Neuropathologica

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1016/0002-9343(83)90403-5

Search In DOI:

ISSN

1432-0533

Search In ISSN:
Search In Title Of Papers:

The multifaceted nature of amyloid precursor prote

Authors: Hoang S Nhan Karen Chiang Edward H Koo
Publish Date: 2014/10/07
Volume: 129, Issue: 1, Pages: 1-19
PDF Link

Abstract

The amyloid precursor protein APP has occupied a central position in Alzheimer’s disease AD pathophysiology in large part due to the seminal role of amyloidβ peptide Aβ a proteolytic fragment derived from APP Although the contribution of Aβ to AD pathogenesis is accepted by many in the research community recent studies have unveiled a more complicated picture of APP’s involvement in neurodegeneration in that other APPderived fragments have been shown to exert pathological influences on neuronal function However not all APPderived peptides are neurotoxic and some even harbor neuroprotective effects In this review we will explore this complex picture by first discussing the pleiotropic effects of the major APPderived peptides cleaved by multiple proteases including soluble APP peptides sAPPα sAPPβ various C and Nterminal fragments p3 and APP intracellular domain fragments In addition we will highlight two interesting sequences within APP that likely contribute to this duality in APP function First it has been found that caspasemediated cleavage of APP in the cytosolic region may release a cytotoxic peptide C31 which plays a role in synapse loss and neuronal death Second recent studies have implicated the –YENPTY– motif in the cytoplasmic region as a domain that modulates several APP activities through phosphorylation and dephosphorylation of the first tyrosine residue Thus this review summarizes the current understanding of various APP proteolytic products and the interplay among them to gain deeper insights into the possible mechanisms underlying neurodegeneration and AD pathophysiology

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Propagation of alpha-synuclein pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies
  2. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update
  3. Occurrence of α-synuclein pathology in the cerebellum of Guamanian patients with parkinsonism-dementia complex
  4. Neuronal and glial accumulation of α- and β-synucleins in human lipidoses
  5. Tauopathy models and human neuropathology: similarities and differences
  6. Clinicopathologic characteristics of sporadic Japanese Creutzfeldt–Jakob disease classified according to prion protein gene polymorphism and prion protein type
  7. Refined brain tumor diagnostics and stratified therapies: the requirement for a multidisciplinary approach
  8. Lack of adrenoleukodystrophy protein enhances oligodendrocyte disturbance and microglia activation in mice with combined Abcd1 / Mag deficiency
  9. Oxidative damage in the olfactory system in Alzheimer's disease
  10. Population-based study on incidence, survival rates, and genetic alterations of low-grade diffuse astrocytomas and oligodendrogliomas
  11. Incidence of axonal injury in human brain tissue
  12. Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy
  13. Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
  14. Common mutations of β-catenin in adamantinomatous craniopharyngiomas but not in other tumours originating from the sellar region
  15. Decreased pyramidal neuron size in Brodmann areas 44 and 45 in patients with autism
  16. In memoriam: Bernd Walter Scheithauer (1946–2011)
  17. Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell death
  18. Acrocallosal syndrome in fetus: focus on additional brain abnormalities
  19. Human pontine glioma cells can induce murine tumors
  20. Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas
  21. Traumatic brain injury-induced axonal phenotypes react differently to treatment
  22. Frequency and clinicopathological characteristics of alcoholic cerebellar degeneration in Japan: a cross-sectional study of 1,509 postmortems
  23. Neuropathologically defined subtypes of Alzheimer’s disease differ significantly from neurofibrillary tangle-predominant dementia
  24. Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH)
  25. Deletion of macrophage migration inhibitory factor attenuates neuronal death and promotes functional recovery after compression-induced spinal cord injury in mice
  26. Unmyelinated nerve fibres in feline acrylamide neuropathy
  27. Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system
  28. Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
  29. Erratum to: Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity
  30. Consensus neuropathological diagnosis of common dementia syndromes: testing and standardising the use of multiple diagnostic criteria
  31. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration
  32. Nothing is wrong with descriptive papers
  33. A model of cerebral aspergillosis in non-immunosuppressed nursing rats
  34. Glucocerebrosidase is present in α-synuclein inclusions in Lewy body disorders
Search Result: