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Title of Journal: Acta Neuropathol

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Abbravation: Acta Neuropathologica

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Springer-Verlag

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DOI

10.1002/pri.1659

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1432-0533

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Deletion of macrophage migration inhibitory factor

Authors: Yutaka Nishio Masao Koda Masayuki Hashimoto Takahito Kamada Shuhei Koshizuka Katsunori Yoshinaga Shin Onodera Jun Nishihira Akihiko Okawa Masashi Yamazaki
Publish Date: 2009/01/06
Volume: 117, Issue: 3, Pages: 321-328
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Abstract

Macrophage migration inhibitory factor MIF is a multipotential protein that acts as a proinflammatory cytokine a pituitary hormone and a cell proliferation and migration factor The objective of this study was to elucidate the role of MIF in spinal cord injury SCI using female MIF knockout KO mice Mouse spinal cord compression injury was produced by application of a static load T8 level 20 g 5 min We analyzed the motor function of the hind limbs and performed histological examinations Hindlimb function recovered significantly in the KO mice starting from three weeks after injury Cresylviolet staining revealed that the number of surviving neurons in the KO mice was significantly larger than that of WT mice six weeks after injury Immunohistochemical analysis revealed that the number of NeuN/caspase3active doublepositive apoptotic neurons in the KO mice was significantly smaller than that of the WT mice 24 and 72 h after SCI These results were related to invitro studies showing increased resistance of cerebellar granular neurons from MIFKO animals to glutamate neurotoxicity These results suggest that MIF existence hinders neuronal survival after SCI Suppression of MIF may attenuate detrimental secondary molecular responses of the injured spinal cord

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