Authors: Kari Hänninen Heikki Katila Marika Saarela Riikka Rontu Kari M Mattila Meng Fan Mikko Hurme Terho Lehtimäki
Publish Date: 2007/09/27
Volume: 258, Issue: 1, Pages: 10-15
Abstract
Interleukin1β IL1β and neuregulin1 NRG1 have an important role in development of the central nervous system Several recent studies suggest that their genetic polymorphisms are associated with schizophrenia We studied the effects of the IL1β gene IL1B 511 and NRG1 SNP8NRG221533 polymorphisms and their interactions on the risk and age of onset of schizophrenia in 113 Finnish schizophrenic patients and 393 healthy controls The allele and genotype frequencies of IL1B and NRG1 did not differ between schizophrenic patients and healthy controls but the risk of schizophrenia was more than 10 times higher odds ratio 1020 95 CI 253–4109 p = 0001 among subjects with the IL1B 22 NRG1 CC genotypes compared to subjects with the IL1B 22 NRG1 Tallele carriage There was also a trend for an association between the interaction between IL1B and NRG1 polymorphisms and the age at onset of schizophrenia χ2 = 280 df = 1 p = 009 log rank test IL1B511 allele 1 homozygotes had a significantly higher age of onset than allele 2 carriers mean age of onset 259 ± 77 and 227 ± 54 years ttest t = 246 p = 0032 Our results suggest that there is an interaction between the IL1B and NRG1 genes in schizophrenia In addition the IL1B511 polymorphism seems to be associated with the age at onset of schizophreniaThe study was supported by grants from the Medical Research Foundation of Tampere University Hospital and special governmental grants for health science research at Helsinki University Central Hospital and South Karelia Central Hospital This work was also supported by grants from the South Karelia Fund of the Finnish Cultural Foundation and the Scholarship Funds of the Vyborg Student Association
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