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Title of Journal: Eur Arch Psychiatry Clin Neurosci

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Abbravation: European Archives of Psychiatry and Clinical Neuroscience

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Springer Berlin Heidelberg

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1433-8491

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Brain activation deficit in increasedload working

Authors: ChihHung Ko JuYu Yen ChengFang Yen ChengSheng Chen WeiChen Lin PengWei Wang GinChung Liu
Publish Date: 2013/05/05
Volume: 263, Issue: 7, Pages: 561-573
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Abstract

Working memory WM is impaired among adults with attentiondeficit hyperactivity disorder ADHD This study aimed to investigate the brain activation deficit for lowlevel or increasedload WM among adults with ADHD A total of 20 adults with ADHD and controls were recruited according to diagnostic interviewing by a psychiatrist Phonological and visual–spatial 2back and 3back tasks were performed under functional magnetic resonance scanning The results demonstrated that both the adults with ADHD and the controls exhibited activation of the frontoparietal network for WM and the intensity was greater in the adult ADHD group The ADHD group had higher brain activation over the bilateral anterior cingulate left inferior frontal lobe hippocampus and supplementary motor area SMA for phonological WM than the control group When the task loading increased from 2back to 3back tasks the adults with ADHD perceived greater difficulty The control group exhibited increased brain activation over the frontal–parietal network in response to increased phonological WM load However the ADHD group showed decreased brain activation over the left precuneus insula and SMA Further analysis demonstrated that the ADHD group exhibited a greater decrease in brain activation over the left frontoparietal network including the precuneus SMA insula/inferior frontal lobe and dorsolateral prefrontal cortex than the control group These results suggest that adults with ADHD pay more effort to low demanding phonological WM On the other hand brain activation of the left frontoparietal network is impaired when the demands of WM exceed the capacity of adults with ADHD

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