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Title of Journal: Eur Arch Psychiatry Clin Neurosc

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Abbravation: European Archives of Psychiatry and Clinical Neuroscience

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D. Steinkopff-Verlag

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DOI

10.1016/0010-4361(78)90617-1

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ISSN

1433-8491

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White matter hyperintensities and their associatio

Authors: Maurizio Pompili Stefan Ehrlich Eleonora De Pisa J John Mann Marco Innamorati Andrea Cittadini Benedetta Montagna Paolo Iliceto Andrea Romano Mario Amore Roberto Tatarelli Paolo Girardi
Publish Date: 2007/09/27
Volume: 257, Issue: 8, Pages: 494-499
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Abstract

A large body of evidence suggests that predisposition to suicide an important public health problem is mediated to a certain extent by neurobiological factors The objective of this crosssectional study was to compare the prevalence of white matter hyperintensities WMH in patients with major affective disorders with and without histories of suicide attemptsT2weighted magnetic resonance images MRI of 65 psychiatric inpatients with major depressive disorder or bipolar disorder were rated for the presence of WMH Diagnoses presence or absence of suicide risk and substance abuse were determined by the Mini International Neuropsychiatric Interview MINI Medical charts were reviewed to ascertain history of suicide attempt and basic clinical variables Fisher’s Exact Tests and logistic regression modeling were used to test the association between WMH and suicidality Suicidal patients and controls were not matched for demographic variables and exposure to some risk factorsBivariate analysis showed that the prevalence of WMH was significantly higher in subjects with past suicide attempts Fisher’s Exact Test p = 001 and other clinical indicators of elevated suicide risk Logistic regression analyses controlling for age sex and several clinical risk factors supported this finding odds ratio = 47 95 confidence interval 14 161The increased prevalence of WMH in adults with major affective disorders and a history of suicide attempt compared to similar patients without such a history is consistent with previous findings in depressed children youth and young adults However the association between WMH and suicidality holds true for both depressed and bipolar patients Our results suggest that WMH in patients with major affective disorders might be useful biological markers of suicidality

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