Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Eur Arch Psychiatry Clin Neurosci

Search In Journal Title:

Abbravation: European Archives of Psychiatry and Clinical Neuroscience

Search In Journal Abbravation:

Publisher

Springer Berlin Heidelberg

Search In Publisher:

DOI

10.1016/j.bbrc.2016.03.096

Search In DOI:

ISSN

1433-8491

Search In ISSN:
Search In Title Of Papers:

Altered apolipoprotein C expression in association

Authors: Christian Knöchel Jonathan Kniep Jason D Cooper Michael Stäblein Sofia Wenzler Jan Sarlon David Prvulovic David E J Linden Sabine Bahn Pawel Stocki Sureyya Ozcan Gilberto Alves Andre F Carvalho Andreas Reif Viola OertelKnöchel
Publish Date: 2016/08/22
Volume: 267, Issue: 3, Pages: 199-212
PDF Link

Abstract

Proteomic analyses facilitate the interpretation of molecular biomarker probes which are very helpful in diagnosing schizophrenia SZ In the current study we attempt to test whether potential differences in plasma protein expressions in SZ and bipolar disorder BD are associated with cognitive deficits and their underlying brain structures Fortytwo plasma proteins of 29 SZ patients 25 BD patients and 93 nonclinical controls were quantified and analysed using multiple reaction monitoringbased triple quadrupole mass spectrometry approach We also computed group comparisons of protein expressions between patients and controls and between SZ and BD patients as well Potential associations of protein levels with cognitive functioning psychomotor speed executive functioning crystallised intelligence as well as underlying brain volume in the hippocampus were explored using bivariate correlation analyses The main finding of this study was that apolipoprotein expression differed between patients and controls and that these alterations in both disease groups were putatively related to cognitive impairments as well as to hippocampus volumes However none of the protein level differences were related to clinical symptom severity In summary altered apolipoprotein expression in BD and SZ was linked to cognitive decline and underlying morphological changes in both disorders Our results suggest that the detection of molecular patterns in association with cognitive performance and its underlying brain morphology is of great importance for understanding of the pathological mechanisms of SZ and BD as well as for supporting the diagnosis and treatment of both disordersMRI was performed at the Frankfurt Brain Imaging Centre supported by the German Research Council DFG and the German Ministry for Education and Research BMBF Brain Imaging Center Frankfurt/Main DLR 01GO0203 We acknowledge the Brazilian National Council of Research CNPq for funding Dr Gilberto Alves who is supported by a postdoctoral scholarship from the CNPq Process 209981/20130 in an exchange cooperation programme with the Goethe University Frankfurt am Main Germany and Dr Andre F Carvalho who receives CNPq research fellowship awards level II Sabine Bahn is a Director and Jason D Cooper and Sureyya Ozcan are consultants of Psynova Neurotech None of the other authors report any conflict of interest Jason Cooper Sabine Bahn and Sureyya Ozcan would like to thank the Stanley Medical Research Institute for centre support The study was reviewed and approved by the ethics committee of the Faculty of medicine Goethe University Frankfurt/Main Germany

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Brain activation deficit in increased-load working memory tasks among adults with ADHD using fMRI
  2. The effect of hypocalcemia in early childhood on autism-related social and communication skills in patients with 22q11 deletion syndrome
  3. Predicting caregiver burden in first admission psychiatric patients
  4. Human dignity and the physician’s conscience
  5. Dysfunction of the blood-cerebrospinal fluid-barrier and N -methyl- d -aspartate glutamate receptor antibodies in dementias
  6. Type of residual symptom and risk of relapse during the continuation/maintenance phase treatment of major depressive disorder with the selective serotonin reuptake inhibitor fluoxetine
  7. Mindfulness-based cognitive therapy for depressed individuals improves suppression of irrelevant mental-sets
  8. Automatic metaphor processing in adults with Asperger syndrome: a metaphor interference effect task
  9. Pharmacotherapy of anxiety disorders in German-speaking countries: current status and changes between 1994 and 2011
  10. The intraindividual impact of ADHD on the transition of adulthood to old age
  11. Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia
  12. An fMRI study of reward circuitry in patients with minimal or extensive history of major depression
  13. Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia
  14. Effects of gender and executive function on visuospatial working memory in adult obsessive–compulsive disorder
  15. White matter hyperintensities and their associations with suicidality in patients with major affective disorders
  16. The interrelation of needs and quality of life in first-episode schizophrenia
  17. The effects of exercise on oxidative stress (TBARS) and BDNF in severely depressed inpatients
  18. Symptom provocation and reduction in patients suffering from spider phobia
  19. Systematic review of the diagnostic utility of SPECT imaging in dementia
Search Result: