Authors: Anwaar Ahmed F Muhammad Anjum Salim Ur Rehman M Atif Randhawa Umar Farooq
Publish Date: 2007/11/15
Volume: 63, Issue: 1, Pages: 7-
Abstract
The bioavailability and interactive effects of calcium iron and zinc fortified whole wheat flour chapattis on female Sprague–Dawley albino rats were determined The whole wheat flour was fortified with CaCO3 FeSO4 and ZnSO4 at 1000 40 and 20 mg/kg respectively and fed to 64 female Sprague–Dawley rats for 4 weeks Retention of Ca Fe and Zn was determined in plasma femur and liver tissues Ca levels in plasma and liver did not alter significantly while the Ca retention in femur changed significantly with the change in fortificants The calcium retention was higher in the femur of rats fed on the diet supplemented with Ca + Zn 221 ± 1361 mg/g than the rats fed on the diet supplemented with Ca + Fe 219 ± 1892 mg/g The iron in plasma liver and femur ranged from 219 ± 011 to 277 ± 010 μg/ml 2035 ± 1324 to 2515 ± 1719 μg/g and 435 ± 105 to 52 ± 207 μg/g while zinc content ranged from 131 ± 0089 to 155 ± 0114 μg/ml 895 ± 341 to 132 ± 610 μg/g and 175 ± 829 to 191 ± 1085 μg/g respectively The minerals interacted with each other resulting in decrease of bioavailability among each other The absorption was higher in the rats fed on fortified diet than those fed on unfortified chapatti diet Hence it is concluded that fortification of whole wheat flour is feasible to overcome the Ca Fe and Zn malnutrition in the vulnerable groups
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