Authors: Dorota Sosnowska Anna Podsędek Małgorzata Redzynia Dorota Żyżelewicz
Publish Date: 2015/07/23
Volume: 70, Issue: 3, Pages: 344-350
Abstract
Pancreatic lipase is the most important enzyme in digestion of triglycerides Reduction of energy intake from dietary fat through inhibition of this enzyme may be a strategy to prevent and treat obesity In this study the effect of 31 fruit extracts on pancreatic lipase was investigated using triolein sunflower oil and rapeseed oil emulsions Surprisingly about 30 of the fruits tested stimulated pancreatic lipase activity in oil emulsions by over 50 Only six fruit extracts were found to inhibit pancreatic lipase activity with the IC50 value varying from 2111 to 26648 mg of fruit equivalent/ml of emulsion Among them chokeberry demonstrated the highest antilipase activity The inhibitory activity ranks were comparable in all lipid emulsion models and suggest that consumption of chokeberry red gooseberry and red currant fruits may be a new dietary option for reduction of fat absorption via inhibition of pancreatic lipaseThe work was funded by the National Science Centre allocated on the basis of Decision No DEC2011/01/B/NZ9/02046 The authors thank Ms Barbara Anders for her technical support in preparing fruit extracts and students Mariola Wesołkowska Sebastian Kmiecik and Marcin Jarzębski for their technical support during determination of lipase activity We also thank Professor Maria Koziołkiewicz for proofreading the manuscript
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