Authors: Koichi Wadasaki Yuko Kaneyasu Masahiro Kenjo Kanji Matsuura Yuji Murakami Yasutoshi Hashimoto Katsuhide Ito Hiroshi Kiriu Atsushi Ito
Publish Date: 2007/02/25
Volume: 12, Issue: 1, Pages: 37-41
Abstract
Between September 1997 and November 2004 57 patients received adjuvant radiotherapy or salvage radiotherapy after radical prostatectomy Fifteen patients received radiation therapy because of positive margins and/or extracapsular invasion in surgical specimens adjuvant group Fortytwo patients received radiation therapy because of rising prostatespecific antigen PSA during followup salvage group Radiation therapy was delivered to the fossa of the prostate ± seminal vesicles by a threedimensional 3D conformal technique to a total dose of 60–66 Gy median 60 Gy Biochemical control was defined as the maintenance of a PSA level of less than 02 ng/mlThe median followup period after radiation therapy was 33 months range 12–98 months Threeyear biochemical control rates were 87 for the adjuvant group and 61 for the salvage group For patients in the salvage group treated without hormone therapy the preradiation PSA value was the most significant factor for the biochemical control rate The 3year biochemical control rate was 93 in patients whose preradiation PSA was 05 ng/ml or less and 29 in patients whose preradiation PSA was more than 05 ng/ml No severe adverse effects equal to or more than grade 3 were seen in treated patientsRadiation therapy after radical prostatectomy seemed to be effective for adjuvant therapy and for salvage therapy in patients with a preradiation PSA of 05 ng/ml or less Also radiation to the fossa of the prostate ± seminal vesicles to a total dose of 60–66 Gy using a threedimensional 3D conformal technique seemed to be safe
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